Inhibitory effect of beta-thujaplicin on ultraviolet B-induced apoptosis in mouse keratinocytes

The Journal of Investigative Dermatology
T BabaY Arima

Abstract

Sunburn cells are thought to represent ultraviolet B-induced apoptotic keratinocytes. It has been demonstrated that enzymatic and nonenzymatic antioxidants effectively suppress sunburn cell formation, indicating that reactive oxygen species may play a role in the progression of ultraviolet B-induced apoptosis. Metallothionein, a cytosol protein, has antioxidant activity, and overexpression of metallothionein has been reported to reduce the number of sunburn cells in mouse skin. We have also demonstrated that overexpression of metallothionein inhibits ultraviolet B-induced DNA ladder formation in mouse keratinocytes. These findings support the hypothesis that cellular metallothionein may play an important role in the inhibition of ultraviolet B-induced apoptosis in keratinocytes through its antioxidant activity. In the present study, we investigated the effects of beta-thujaplicin, an extract from the woods of Thuja plicata D. Don. and Chamaecyparis obtuse, Sieb. et Zucc., on ultraviolet B-induced apoptosis in keratinocytes and on metallothionein induction. Topical application of beta-thujaplicin decreased the number of ultraviolet B-mediated sunburn cells and terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick...Continue Reading

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Citations

Oct 2, 2003·Bioscience, Biotechnology, and Biochemistry·Hitoshi ShibataYoshihiro Sawa
Jan 17, 2008·Drug Delivery·Hyang Hee JooHyeon Yong Lee
Apr 2, 2008·International Journal of Cosmetic Science·Y OchiaiH Sakurai
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Jan 18, 2014·Platelets·Wan-Jung LuJoen-Rong Sheu
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Mar 23, 2018·International Journal of Molecular Sciences·Thanasekaran JayakumarJoen-Rong Sheu
Apr 15, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Paola F LiguoriDaniela Pucci
Jul 13, 2016·Archiv der Pharmazie·Theano FotopoulouMaria Koufaki
Dec 15, 2018·Journal of Cellular and Molecular Medicine·Wan-Jung LuRay-Jade Chen
Mar 17, 2017·Journal of Cutaneous Medicine and Surgery·Sophia Colantonio, Jason K Rivers

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis