Inhibitory effect of Bifidobacterium bifidum ATCC 29521 on colitis and its mechanism.

The Journal of Nutritional Biochemistry
Ahmad Ud DinGuixue Wang

Abstract

Probiotics are known to be beneficial in preventing different diseases in model animals, including inflammatory bowel disease. However, there are few studies on probiotics related to miRNA regulation and disease status. In this article, the beneficial role and mechanisms of the probiotic strain Bifidobacterium bifidum ATCC 29521 have been studied in ulcerative colitis using dextran sodium sulphate (DSS) model. Male C57JBL/6 mice were randomly divided into three groups (n=7): Normal group, dextran sulphate sodium (DSS) group, and Bifido group gavage with Bifidobacterium bifidum ATCC 29521 (2×108 CFU/day). Our strain restored the DSS-caused damage by regulating the expression of immune markers and tight junction proteins (TJP) in the colon; briefly by up-regulating ROS-scavenging enzymes (SOD1, SOD2, CAT, and GPX2), anti-inflammatory cytokines (IL-10, PPARγ, IL-6), TJP's (ZO-1, MUC-2, Claudin-3, and E Cadherin-1) and downregulating inflammatory genes (TNF-α, IL-1β) in Bifido group mice. Inflammatory markers appeared to be regulated by NF-κB nuclear P65 subunit, and its translocation was inhibited in Bifido group mice colon. In addition, the expression of inflammatory genes and colonic TJP were also associated with the restoration...Continue Reading

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Aug 23, 2020·International Journal of Molecular Sciences·Yi-Hsun ChenMing-Shiang Wu
Nov 17, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ahmad Ud DinJianbo Wu
Jul 14, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xiao-Xiao LiClara Bik-San Lau
Oct 9, 2021·Journal of Molecular Histology·Siwen TangJinghua Liang

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