Inhibitory effect of caveolin-1 in vascular endothelial cells, pericytes and smooth muscle cells

Oncotarget
Hongping XuZhongshu Tang

Abstract

Caveolin-1 (Cav1) is the principle structural protein of caveolae. It plays important roles in the vascular system under both physiological and pathological conditions. Although Cav1 has been shown to inhibit microvascular permeability and has been considered as a tumor-suppressor for years, the underlying cellular mechanism has yet to be discovered. Here, we systematically investigated Cav1 functions in the main types of vascular cells, including endothelial cells (ECs), pericytes (PCs) and smooth muscle cells (SMCs). We synthesized a cell-permeable peptide called cavtratin that is derived from the Cav1 scaffolding domain. We found that cavtratin inhibited ECs in all assays, including survival, proliferation, migration and permeability assays. It also inhibited the proliferation of PCs and SMCs but had no effect on their survival or migration. The inhibitory effect of cavtratin on the proliferation of all vascular cells suggests that Cav1 plays important roles in vascular development and angiogenesis. Under physiological condition, the main function of Cav1 is to inhibit EC permeability.

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Citations

Aug 7, 2019·Biomolecules·Rohan SamarakoonPaul J Higgins
Mar 11, 2018·International Journal of Cancer. Journal International Du Cancer·Julia Ketteler, Diana Klein
Jul 16, 2019·Pathology, Research and Practice·Cunye YanBenzhong Wang
Apr 11, 2021·Proceedings of the National Academy of Sciences of the United States of America·Salina GairheRobert L Danner
Apr 20, 2021·Frontiers in Oncology·Andrej PanicDiana Klein
Jan 30, 2021·The European Respiratory Journal·Colin E EvansYou-Yang Zhao

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