Inhibitory Effect of Chebulic Acid on Alveolar Epithelial to Mesenchymal Transition in Response to Urban Particulate Matter Using Co-treatment and Post-treatment Exposure

Biological & Pharmaceutical Bulletin
Hee-Ra LeeKwang-Won Lee

Abstract

Urban particulate matter (UPM) is atmospheric particulate samples obtained from industrialized urban areas. It is known that pulmonary fibrosis can result directly or indirectly from particulate matter. In this study, the protective effect of chebulic acid (CA) against UPM-induced epithelial-mesenchymal transition (EMT) in the pulmonary alveolar epithelial (PAE) cells were investigated. Our findings revealed that PAE cells were changed from the epithelial phenotype to mesenchymal one after exposure to UPM. Furthermore, co-treatment and post-treatment of CA inhibited EMT progression. Especially the key epithelial marker, E-cadherin, was down-regulated by UPM and recovered by CA. Also, gelatin zymogram showed that the activity of matrix metalloproteinase (MMP)-2 and MMP-9 was decreased by co-treatment and post-treatment of CA. Further investigation revealed that CA attenuated UPM-stimulated PAE cells invasion ability. These data showed that UPM promoted PAE cells invasion, reactive oxygen species-mediated extracellular matrix degradation and CA reduced the potential health risks associated with UPM.

References

May 26, 2005·Chemosphere·Byeong-Kyu LeeHaengah Kim Lee
Jun 11, 2005·Respiratory Research·Hidenori KasaiZhi Zhang
Aug 27, 2005·Oncogene·Jiri Zavadil, Erwin P Böttinger
Sep 6, 2005·Biological & Pharmaceutical Bulletin·Hyun-Sun LeeKwang-Won Lee
Feb 18, 2006·American Journal of Respiratory Cell and Molecular Biology·Vijay DasariNancy McNamara
Feb 24, 2007·Nature Reviews. Molecular Cell Biology·Andrea Page-McCawZena Werb
Apr 25, 2007·Apoptosis : an International Journal on Programmed Cell Death·Martin OttBoris Zhivotovsky
Feb 21, 2008·Clinical & Experimental Metastasis·Lidiya S Orlichenko, Derek C Radisky
Mar 1, 2012·International Review of Cell and Molecular Biology·KangAe Lee, Celeste M Nelson
Apr 27, 2013·Asian Pacific Journal of Tropical Biomedicine·Anwesa BagRabi Ranjan Chattopadhyay
May 21, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Xiaobei DengWenjun Ding
Oct 9, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Robert J MitkusKatherine S Squibb
Nov 10, 2013·Nature Medicine·Wai Leong Tam, Robert A Weinberg
Apr 12, 2014·Apoptosis : an International Journal on Programmed Cell Death·Xiaobei DengWenjun Ding
Sep 9, 2015·Temperature : Multidisciplinary Biomedical Journal·Manuel Sanchez-AlavezMaria Cecilia G Marcondes
Nov 11, 2015·Combinatorial Chemistry & High Throughput Screening·Yang ShuYu-Dong Cai
Jul 21, 2017·BMC Complementary and Alternative Medicine·Kyung-Won LeeKwang-Won Lee
Oct 29, 2017·Proceedings of the National Academy of Sciences of the United States of America·Xiaobo LiRui Chen
Apr 2, 2019·Physical Review Letters·M AblikimUNKNOWN BESIII Collaboration

❮ Previous
Next ❯

Citations

Sep 15, 2020·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Margaux CochardYann Landkocz
Mar 11, 2021·The Journal of Experimental Medicine·Jing QuYong Zhou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.