Inhibitory Effect of Chemical Constituents Isolated from Artemisia iwayomogi on Polyol Pathway and Simultaneous Quantification of Major Bioactive Compounds

BioMed Research International
Yoon Kyoung LeeWan Kyunn Whang

Abstract

Blocking the polyol pathway plays an important role preventing diabetic complications. Therefore, aldose reductase (AR) and advanced glycation endproducts (AGEs) formation has significant effect on diabetic complications. Artemisia iwayomogi has long been used as treatment of various diseases in Korea. However, no literatures have reported on AR and AGEs formation inhibitory activities of A. iwayomogi. For these reasons, we aimed to assess that A. iwayomogi had potential as anti-diabetic complications agents. We led to isolation of two coumarins (1 and 2), nine flavonoids (3-11), five caffeoylquinic acids (12-16), three diterpene glycosides (17-19), and one phenolic compound (20) from A. iwayomogi. Among them, hispidulin (4), 6-methoxytricin (6), arteanoflavone (7), quercetin-3-gentiobioside (10), 1,3-di-O-caffeoylquinic acid (13), and suavioside A (18) were first reported on the isolation from A. iwayomogi. Not only two coumarins (1 and 2), nine flavonoids (3-11), and five caffeoylquinic acids (12-16) but also extracts showed significant inhibitor on AR and AGEs formation activities. We analyzed contents of major bioactive compounds in Korea's various regions of A. iwayomogi. Overall, we selected Yangyang, Gangwon-do, from Jun...Continue Reading

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Citations

May 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Amna ParveenWhang Wan Kyunn
Sep 30, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yoon Kyoung LeeWan Kyunn Whang
Dec 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jun Hee Park, Wan Kyunn Whang
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sojeong KimSang-Jip Nam

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Methods Mentioned

BETA
NMR
column chromatography
Fluorescence

Software Mentioned

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