Inhibitory effect of cilnidipine on vascular sympathetic neurotransmission and subsequent vasoconstriction in spontaneously hypertensive rats

Japanese Journal of Pharmacology
M HosonoH Kato

Abstract

We reported previously that cilnidipine inhibited increases in blood pressure and plasma norepinephrine (NE) level in response to cold stress in spontaneously hypertensive rats (SHRs). In the present study, we investigated the effect of cilnidipine on sympathetic neurotransmission and subsequent vasoconstriction in SHRs. In pithed SHRs, electrical sympathetic nerve stimulation (ESNS) elevated blood pressure, and this pressor response was abolished by guanethidine. Cilnidipine at 10 micrograms/kg, i.v. and phentolamine at 1 mg/kg, i.v. suppressed the pressor response to ESNS by 28 +/- 6% and 67 +/- 3%, respectively. Neither nifedipine nor nicardipine inhibited it. The pressor response to exogenous NE was not influenced by cilnidipine. alpha, beta-Methylene ATP inhibited the pressor response to ESNS in the presence or absence of phentolamine. Cilnidipine also attenuated the phentolamine-resistant pressor response to ESNS. In SHR mesenteric vasculatures preloaded with [3H]-NE, cilnidipine (10(-7) M) as well as omega-conotoxin significantly inhibited the 3H overflow evoked by periarterial nerve stimulation. In radioligand binding experiments, cilnidipine inhibited [125I]-omega-conotoxin binding to rat synaptosomes, but it did not i...Continue Reading

References

May 1, 1979·European Journal of Pharmacology·P Greengrass, R Bremner
Sep 1, 1991·Japanese Journal of Pharmacology·M NakashimaH Suzuki
Jan 1, 1991·Physiological Reviews·J A Herd
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E W McCleskeyD Yoshikami
May 1, 1988·British Journal of Pharmacology·J M Bulloch, J C McGrath
Jan 1, 1989·British Journal of Pharmacology·B ClasbrummelP Illes
Jun 1, 1984·European Journal of Pharmacology·H KarakiN Urakawa

❮ Previous
Next ❯

Citations

Jan 5, 2002·European Journal of Pharmacology·Akira TakaharaSeinosuke Iwata
Jun 18, 1997·European Journal of Pharmacology·K AyajikiN Toda
Jul 17, 1999·European Journal of Pharmacology·H UneyamaN Akaike
Oct 1, 2010·The Keio Journal of Medicine·Koichi HayashiHiroshi Itoh
Oct 6, 2009·Biological & Pharmaceutical Bulletin·Hajime KoganeiSeinosuke Iwata
Dec 16, 2000·Expert Opinion on Investigational Drugs·Y Matsumura, K Hayashi
Apr 24, 2009·Clinical and Experimental Hypertension : CHE·Takuya KishiKenji Sunagawa
Nov 24, 2005·Clinical and Experimental Hypertension : CHE·Takuya TsuchihashiKenichi Goto
Sep 2, 2008·Journal of Pharmacological Sciences·Nobuaki EgashiraMichihiro Fujiwara
Oct 5, 2016·Expert Opinion on Investigational Drugs·J Tamargo, Luis Miguel Ruilope
Nov 20, 2004·Journal of Cardiovascular Pharmacology·Toshio KushiroKatsuo Kanmatsuse
May 19, 2004·Fundamental & Clinical Pharmacology·Alexander NapPieter A van Zwieten
Nov 19, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Akira TakaharaHiroshi Yamamoto
Mar 12, 2002·Japanese Journal of Pharmacology·T OkamuraK Ayajiki
Jul 24, 2004·Journal of Pharmacological Sciences·Yoshinobu TakataHitoshi Kato
Feb 20, 2007·Circulation Research·Koichi HayashiTakao Saruta
Jul 23, 1998·Clinical and Experimental Pharmacology & Physiology·K NoguchiM Sakanashi
Nov 29, 2007·Heart and Vessels·Tsuyoshi ShigaHiroshi Kasanuki
Sep 22, 2007·Journal of Hypertension·Satoshi MorimotoToshiji Iwasaka
Sep 6, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hiroshi NagaiHisayoshi Fujiwara
Aug 21, 2001·Hypertension Research : Official Journal of the Japanese Society of Hypertension·G W RoseH Suzuki
May 8, 2019·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Fumiko YamakiYoshio Tanaka
Apr 8, 2003·European Journal of Pharmacology·Ryuji UchidaKenji Kitamura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.