PMID: 15228216Jul 2, 2004Paper

Inhibitory effect of coffee on hepatoma proliferation and invasion in culture and on tumor growth, metastasis and abnormal lipoprotein profiles in hepatoma-bearing rats

Journal of Nutritional Science and Vitaminology
Yutaka MiuraKazumi Yagasaki

Abstract

We have already reported that instant coffee powder (ICP) and ICP-loaded rat sera could suppress proliferation and invasion of rat ascites hepatoma cell line of AH109A in vitro. In this report, we examined the mechanisms for suppression of tumor cell proliferation and invasion by ICP, and the effect of ICP on in vivo tumor growth, metastasis and abnormal lipoprotein profiles in hepatoma-bearing rats. ICP, when directly added to the culture media, induced cell cycle arrest (elongation of S phase) at a lower concentration (0.3 mg/mL) and apoptosis at a higher concentration (0.6-1.2 mg/mL). ICP and ICP-loaded rat sera showed reactive oxygen species (ROS)-scavenging property and canceled the enhancement of invasive activity of hepatoma cells induced by ROS in vitro. These results suggest that ICP suppresses the proliferation by inducing cell cycle arrest and apoptosis, and the invasion by scavenging ROS and that ICP could retain these properties after their gastrointestinal absorption. The hepatoma-bearing rats were fed with a 20% casein diet (20C) or 20C supplemented with 0.1%, ICP for 14 d. Dietary ICP significantly reduced solid tumor growth and tended to reduce hepatoma metastases to lung and lymphatic nodes, suggesting that IC...Continue Reading

Citations

Apr 2, 2010·Nutrition and Cancer·Eliane M Silva-OliveiraTasso Moraes-Santos
Jun 15, 2007·Journal of Zhejiang University. Science. B·Jing-Ting JiangChang-Ping Wu
Nov 6, 2008·Molecular Nutrition & Food Research·Andy H LeeColin W Binns
Feb 24, 2015·Nutrition and Cancer·Huan LiuYun-Fei Xu
Jan 27, 2017·Nutrients·Federico SalomoneGiovanni Li Volti
Dec 17, 2008·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Christopher D MannDavid P Berry
May 2, 2019·British Journal of Cancer·Kim Tu TranChris R Cardwell
Dec 4, 2019·Japanese Journal of Clinical Oncology·Keitaro TanakaUNKNOWN Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan
Jun 12, 2021·Oxidative Medicine and Cellular Longevity·Ayelén D NigraGermán A Gil

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