Inhibitory Effect of Crocin(s) on Lens α-Crystallin Glycation and Aggregation, Results in the Decrease of the Risk of Diabetic Cataract

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Fereshteh BahmaniArezou Ghahghaei

Abstract

The current study investigates the inhibitory effect of crocin(s), also known as saffron apocarotenoids, on protein glycation and aggregation in diabetic rats, and α-crystallin glycation. Thus, crocin(s) were administered by intraperitoneal injection to normal and streptozotocin-induced diabetic rats. The cataract progression was recorded regularly every two weeks and was classified into four stages. After eight weeks, the animals were sacrificed and the parameters involved in the cataract formation were measured in the animal lenses. Some parameters were also determined in the serum and blood of the rats. In addition, the effect of crocin(s) on the structure and chaperone activity of α-crystallin in the presence of glucose was studied by different methods. Crocin(s) lowered serum glucose levels of diabetic rats and effectively maintained plasma total antioxidants, glutathione levels and catalase activity in the lens of the animals. In the in vitro study, crocin(s) inhibited α-crystallin glycation and aggregation. Advanced glycation end products fluorescence, hydrophobicity and protein cross-links were also decreased in the presence of crocin(s). In addition, the decreased chaperone activity of α-crystallin in the presence of g...Continue Reading

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Citations

Dec 28, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Tsimidou, Petros A Tarantilis
Jun 5, 2018·Fundamental & Clinical Pharmacology·Amany Abdel-GhaffarRawda G Mohamed
Sep 21, 2019·Journal of Biomolecular Structure & Dynamics·S Ali HashemiMohammad-Ali Mohagheghi
Feb 3, 2018·Electrophoresis·Anastasia Kyriakoudi, Maria Z Tsimidou
Aug 25, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yosuke NakazawaHiroomi Tamura

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Methods Mentioned

BETA
circular dichroism
electrophoresis
size-exclusion chromatography

Software Mentioned

SPSS

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