Inhibitory effect of cyclic AMP on phorbol ester-stimulated production of reactive oxygen metabolites in rat glomeruli.

Biochemical and Biophysical Research Communications
A MiyanoshitaH Endou

Abstract

Studies were conducted to investigate cross-talk between protein kinase C (PKC) and cyclic AMP (cAMP) pathways using rat glomeruli (Glm). Phorbol 12-myristate 13-acetate (PMA), a PKC activator, stimulated production of reactive oxygen metabolites (ROM) in Glm. Forskolin and dibutyryl cAMP (Bt2cAMP) inhibited production of ROM dose-dependently. In the presence of both Bt2cAMP and 3-isobutyl-1-methylxanthine (IBMX) an additive effect was observed. Forskolin at 10(-4) inhibited translocation of PKC from the cytosol to the membrane. These results demonstrate that cAMP-mediated inhibition can occur at a step distal to PKC activation.

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Citations

Nov 30, 1995·Molecular and Cellular Endocrinology·S I MyersB Kalley-Taylor
Aug 16, 1994·European Journal of Pharmacology·M BevilacquaG Norbiato
Dec 10, 1999·Diabetes Research and Clinical Practice·H Ha, K H Kim
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May 6, 1991·Biochimica Et Biophysica Acta·A R Cross, O T Jones
Sep 1, 1996·Japanese Journal of Pharmacology·Y Kawai, M Gemba

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