PMID: 9533630Apr 9, 1998Paper

Inhibitory effect of cyclosporin A peptide on rat hepatocytes proliferation induced by mitogens

Peptides
N Rodríguez-HencheL G Guijarro

Abstract

Treatment of cultured rat hepatocytes with cyclosporin A (0.01-1 microM) for 24, 48, or 72 h in the presence of insulin and epidermal growth factor induced an inhibition on cell proliferation in a time- and concentration-dependent manner, with an IC50 = 0.05 microM CsA corresponding to 48-h treatment. The inhibitory effect of CsA at < or = 0.1 microM doses for 48 h on [3H]thymidine uptake was reversed after withdrawal of the drug and subsequent addition of insulin plus EGF or serum; however, at 1 microM CsA the effect was irreversible and numerous bright small vesicles were observed. The molecular mechanism involved in CsA action in hepatocytes seems to be independent on cAMP and pertussis-toxin sensitive G proteins.

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Citations

Aug 29, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Oscar EscribanoLuis G Guijarro
Dec 7, 2007·Biotechnology & Genetic Engineering Reviews·Kai HilperRobert E W Hancock
Jul 1, 2004·The Journal of Pharmacology and Experimental Therapeutics·César MenorLuis G Guijarro

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