Inhibitory effect of desoxyrhaponticin and rhaponticin, two natural stilbene glycosides from the Tibetan nutritional food Rheum tanguticum Maxim. ex Balf., on fatty acid synthase and human breast cancer cells

Food & Function
Ping LiXiaofeng Ma

Abstract

Fatty acid synthase (FAS) has attracted more and more attention as a potential target for cancer treatment. Natural FAS inhibitors are emerging as potential therapeutic agents to treat cancer. Rheum tanguticum Maxim. ex Balf. (rhubarb) is a traditional Chinese nutritional food and has been reported to possess a variety of biological activities, including the ability to induce the apoptosis of cancer cells. This study indicates that desoxyrhaponticin (DC) and rhaponticin (RC), two stilbene glycosides from rhubarb, could be considered as promising FAS inhibitors. We found that both DC and RC could inhibit intracellular FAS activity and downregulate FAS expression in human breast cancer MCF-7 cells. In addition, the apoptotic effect of DC on human cancer cells was announced for the first time. Since FAS plays a key role in the biosynthesis pathway of fatty acids in cancer cells, these findings suggest that DC has potential applications in the prevention and treatment of cancer.

References

Sep 1, 1977·Chemical & Pharmaceutical Bulletin·G NonakaI Nishioka
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·A JayakumarS J Wakil
Dec 4, 2001·European Journal of Pharmacology·H Z LeeC H Wu
Feb 22, 2002·International Journal of Cancer. Journal International Du Cancer·Johannes V SwinnenGuido Verhoeven
Jun 17, 2006·Cancer Research·Francis P Kuhajda
Oct 6, 2006·Medicinal Research Reviews·Qing HuangChoon Nam Ong
Feb 14, 2007·Cancer Biology & Therapy·Jay F Dorsey, Gary D Kao
Sep 21, 2007·Nature Reviews. Cancer·Javier A Menendez, Ruth Lupu
Apr 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hajime OritaEdward Gabrielson
Jul 16, 2008·Antimicrobial Agents and Chemotherapy·Won-Hwan ParkHyung-In Moon
Sep 3, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kim WalterMichael Goggins
Apr 9, 2010·Future Oncology·Richard FlavinMassimo Loda
Jul 9, 2010·CA: a Cancer Journal for Clinicians·Ahmedin JemalElizabeth Ward

❮ Previous
Next ❯

Citations

Aug 17, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yi LuoPeng Zhao
Feb 13, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yan ZhouLi Lin
Feb 5, 2016·Journal of Cellular Physiology·William B KinlawNancy B Kuemmerle
Nov 22, 2018·Journal of the Science of Food and Agriculture·Feng XiongGuoying Zhou
Apr 4, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Graham ThomasRichard N Hanna
May 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marcin CzopJanusz Kocki
Aug 24, 2021·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Amina M DirirLina F Yousef

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis