Inhibitory effect of dietary lipids on chaperone-mediated autophagy.

Proceedings of the National Academy of Sciences of the United States of America
Jose Antonio Rodriguez-NavarroAna Maria Cuervo

Abstract

Cytosolic proteins can be selectively delivered to lysosomes for degradation through a type of autophagy known as chaperone-mediated autophagy (CMA). CMA contributes to intracellular quality control and to the cellular response to stress. Compromised CMA has been described in aging and in different age-related disorders. CMA substrates cross the lysosomal membrane through a translocation complex; consequently, changes in the properties of the lysosomal membrane should have a marked impact on CMA activity. In this work, we have analyzed the impact that dietary intake of lipids has on CMA activity. We have found that chronic exposure to a high-fat diet or acute exposure to a cholesterol-enriched diet both have an inhibitory effect on CMA. Lysosomes from livers of lipid-challenged mice had a marked decrease in the levels of the CMA receptor, the lysosome-associated membrane protein type 2A, because of loss of its stability at the lysosomal membrane. This accelerated degradation of lysosome-associated membrane protein type 2A, also described as the mechanism that determines the decline in CMA activity with age, results from its increased mobilization to specific lipid regions at the lysosomal membrane. Comparative lipidomic analyse...Continue Reading

References

Aug 1, 1990·Trends in Biochemical Sciences·J F Dice
May 19, 1997·The Journal of Cell Biology·F A AgarraberesJ F Dice
Aug 7, 1998·Molecular Biology of the Cell·A M CuervoJ F Dice
May 12, 2000·The Journal of Biological Chemistry·A M Cuervo, J F Dice
Feb 24, 2001·Traffic·A M Cuervo, J F Dice
Apr 4, 2003·The International Journal of Biochemistry & Cell Biology·Sophie VigourouxMariele Briand
May 20, 2004·Kidney International·Sira SooparbHarold A Franch
Aug 28, 2004·Molecular Biology of the Cell·Roberta KiffinAna Maria Cuervo
May 17, 2005·Immunity·Delu ZhouJanice S Blum
Sep 30, 2005·Traffic·Eeva-Liisa EskelinenPaul Saftig
Apr 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ashish C MasseyAna Maria Cuervo
Apr 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Mei-Chi HsuIan C M Maclennan
Aug 19, 2006·The EMBO Journal·Susmita KaushikAna Maria Cuervo
Feb 8, 2007·Journal of Cell Science·Roberta KiffinAna Maria Cuervo
Feb 29, 2008·Nature·Noboru MizushimaDaniel J Klionsky
Mar 14, 2008·Molecular Biology of the Cell·Susmita KaushikAna Maria Cuervo
Jul 23, 2008·Molecular and Cellular Biology·Urmi BandyopadhyayAna Maria Cuervo
Oct 14, 2008·Biochimica Et Biophysica Acta·Félix M Goñi, Alicia Alonso
Oct 28, 2008·Biochimica Et Biophysica Acta·Félix M GoñiJenifer L Thewalt
Feb 10, 2009·Methods in Enzymology·Susmita Kaushik, Ana Maria Cuervo
Apr 3, 2009·Nature·Rajat SinghMark J Czaja
Aug 6, 2009·Human Molecular Genetics·Yipeng WangEckhard Mandelkow
Oct 28, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·F Hullin-MatsudaI Delton-Vandenbroucke
Oct 28, 2009·Trends in Endocrinology and Metabolism : TEM·Ana Maria Cuervo
Dec 23, 2009·FEBS Letters·Maria Kon, Ana Maria Cuervo
Mar 5, 2010·The Journal of Biological Chemistry·Sally K MakDonato A Di Monte
Apr 9, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hiroshi KogaAna Maria Cuervo
Jun 29, 2010·Nature Neuroscience·Esther Wong, Ana Maria Cuervo
Jul 22, 2010·Autophagy·Hiroshi KogaAna Maria Cuervo
Nov 5, 2010·Diabetes, Obesity & Metabolism·S KaushikA M Cuervo
Jan 18, 2011·Developmental Cell·Ranjit SahuLaura Santambrogio
Jan 27, 2011·Nature Communications·Claudia Dall'ArmiGilbert Di Paolo
Feb 2, 2011·Journal of Cell Science·Susmita KaushikAna Maria Cuervo
Apr 26, 2011·Biochimica Et Biophysica Acta·Shishir Jaikishan, J Peter Slotte
Jul 14, 2011·Nature Communications·Hiroshi KogaAna Maria Cuervo

❮ Previous
Next ❯

Citations

Jan 19, 2013·Circulation Research·Xuejun WangHuabo Su
Nov 28, 2013·Cell Research·Ana Maria Cuervo, Esther Wong
Nov 7, 2013·Nature Reviews. Gastroenterology & Hepatology·Jaime L Schneider, Ana Maria Cuervo
Apr 18, 2016·Metabolism: Clinical and Experimental·Karen A WeikelJosé M Cacicedo
Jan 19, 2016·Biochimica Et Biophysica Acta·Carl WardViktor I Korolchuk
Oct 11, 2015·Gastroenterology·Julio Madrigal-Matute, Ana Maria Cuervo
Feb 4, 2014·Seminars in Nephrology·Harold A Franch
Jul 4, 2012·Trends in Cell Biology·Susmita Kaushik, Ana Maria Cuervo
Jan 5, 2016·Digestive Diseases and Sciences·Mark J Czaja
Mar 8, 2016·Ageing Research Reviews·Raquel Gómez-SintesPatricia Boya
Jul 22, 2014·Cell Metabolism·Jaime L SchneiderAna Maria Cuervo
Dec 22, 2012·The EMBO Journal·Sunandini SridharAna Maria Cuervo
Jan 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Karen E MurphyGlenda M Halliday
Jan 18, 2015·Biochimica Et Biophysica Acta·Aleksandr Stotland, Roberta A Gottlieb
Aug 26, 2014·Amino Acids·Eloy Bejarano, José Antonio Rodríguez-Navarro
Jun 4, 2014·Neuropathology and Applied Neurobiology·Nils MarschalekThomas Georg Ohm
Jan 27, 2015·Aging Cell·Jaime L SchneiderAna Maria Cuervo
Jun 23, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Matthew E GeggAnthony H V Schapira
May 12, 2015·Nature Cell Biology·Susmita Kaushik, Ana Maria Cuervo
Apr 7, 2015·Seminars in Cell & Developmental Biology·Marta Martinez-Vicente
Jun 19, 2013·Autophagy·Mark J CzajaXiao-Ming Yin
Jul 26, 2014·Trends in Cell Biology·Carmine Settembre, Andrea Ballabio
Jan 12, 2013·Current Biology : CB·Claudia Dall'ArmiGilbert Di Paolo
Jun 8, 2014·Current Opinion in Genetics & Development·Jaime L Schneider, Ana Maria Cuervo
Nov 5, 2014·Acta Neuropathologica·Markus DammeEeva-Liisa Eskelinen
Feb 6, 2015·The Journal of Clinical Investigation·Frank MadeoGuido Kroemer
Feb 9, 2016·The FEBS Journal·Inmaculada Tasset, Ana Maria Cuervo
Aug 4, 2016·Ageing Research Reviews·Maria Xilouri, Leonidas Stefanis
Nov 4, 2016·Nature Reviews. Endocrinology·Andrei BaiceanuFabienne Foufelle
Sep 14, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Lauren R Kett, William T Dauer
Oct 22, 2016·Biochimica Et Biophysica Acta·Purvi C TrivediThomas Pulinilkunnil
Aug 9, 2016·Annual Review of Cell and Developmental Biology·Rushika M Perera, Roberto Zoncu
Feb 6, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Joe Antony JacobBaoan Chen
Jun 23, 2016·Journal of Lipid Research·Bharat Jaishy, E Dale Abel
Dec 4, 2015·Journal of Lipid Research·Marta Gómez de Cedrón, Ana Ramírez de Molina
Dec 17, 2017·The Journal of Biological Chemistry·Kumsal Tekirdag, Ana Maria Cuervo
Feb 11, 2018·Cellular and Molecular Life Sciences : CMLS·Ana L Santos, Giulio Preta
Dec 1, 2017·The Journal of Cell Biology·Zhenwei GongRadhika Muzumdar
Apr 8, 2018·Nature Reviews. Molecular Cell Biology·Susmita Kaushik, Ana Maria Cuervo
Dec 14, 2017·Essays in Biochemistry·Steve CatarinoHenrique Girão
Sep 7, 2018·Expert Opinion on Therapeutic Targets·Philip CampbellAnthony Schapira

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Related Papers

The Journal of Biological Chemistry
Ana Maria Cuervo, J Fred Dice
Current Opinion in Cell Biology
Esperanza Arias, Ana Maria Cuervo
Seminars in Cell & Developmental Biology
Samantha J Orenstein, Ana Maria Cuervo
Methods in Enzymology
Susmita Kaushik, Ana Maria Cuervo
© 2022 Meta ULC. All rights reserved