PMID: 8958778Nov 1, 1996Paper

Inhibitory effect of dihydrotestosterone on human thyroid cell growth

The Journal of Endocrinology
R RossiL del Senno

Abstract

Sex steroid-binding activities have been identified by several authors in normal and pathological thyroids and the expression of the canonic androgen receptor (AR) has recently been demonstrated in human thyroid follicular cells. In order to assess what influence, if any, androgen exposure has on thyroid cell growth, the effect of dihydrotestosterone (DHT) on [3H]thymidine (thy) incorporation and cell proliferation was investigated in thyroid follicular cells in vitro. In a primary culture of goitrous cells, DHT induced a significant reduction of [3H]thy incorporation at concentrations ranging from 10(-12) to 10(-8) M, with a more pronounced effect at 10(-9) M. At this concentration, the inhibitory effect was evident after both 24 and 48 h of treatment and in various types of primary thyroid cell cultures. In goitrous cells, the DHT-induced decrease of [3H]thy was associated with a reduction of expression of the proliferation-associated nuclear Ki-67 antigen, a protein commonly used to assess cell growth fraction. In TPC cells, an AR-positive thyroid papillary carcinoma cell line, DHT at concentrations between 10(-12) and 10(-8) M significantly decreased the growth rate. DHT (10(-9) M) produced an approximately 50-60% inhibitio...Continue Reading

Citations

Dec 19, 2002·Thyroid : Official Journal of the American Thyroid Association·Nils KnudsenTorben Jørgensen
Nov 8, 2008·The American Journal of Pathology·Yi-Kang ShiJian-Hua Luo
Nov 5, 1997·General and Comparative Endocrinology·N L Staub, M De Beer
Aug 25, 2016·American Journal of Reproductive Immunology : AJRI·Yerbol BekmukhambetovMaral Bekzhanova
Oct 21, 2017·Digestive Diseases and Sciences·Helen M PalethorpeEric Smith
Nov 22, 2017·International Journal of Endocrinology·Yunzhao TangChanglin Ni
Aug 8, 2019·Journal of Clinical Pharmacology·Robert KrysiakBogusław Okopień
Aug 4, 2020·Asian Journal of Urology·Renee E VickmanSimon W Hayward
Apr 21, 2021·Journal of Cellular Biochemistry·Melanie E JonesJan Geliebter

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