Inhibitory effect of ethanol on endothelium-dependent vascular responsiveness

European Journal of Pharmacology
K HatakeS Hishida

Abstract

The effect of ethanol was studied on the endothelium-dependent vascular responses in isolated rat aortic strips. Ethanol depressed the endothelium-dependent relaxation induced by acetylcholine and ATP but not that induced by the calcium ionophore, A23187. Endothelium-independent relaxation in response to sodium nitroprusside, a soluble guanylate cyclase activator, was not depressed by ethanol. On the other hand, ethanol significantly enhanced the contractile response to clonidine, an alpha 2-adrenoceptor agonist, in endothelium-intact strips and depressed it in endothelium-denuded strips. These results suggest that ethanol can inhibit endothelium-dependent relaxation by acting on endothelial cells but not on smooth muscle cells, and can also suppress an inhibitory effect of the endothelium on alpha 2-adrenoceptor-mediated vasoconstriction.

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Citations

Jul 20, 1993·European Journal of Pharmacology·K HatakeS Hishida
Mar 11, 1994·European Journal of Pharmacology·A L BrizzolaraG Burnstock
Oct 1, 1993·European Journal of Pharmacology·A ZhangB M Altura
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Aug 1, 1994·Alcoholism, Clinical and Experimental Research·K HatakeS Hishida
Jun 1, 1994·Alcoholism, Clinical and Experimental Research·E T Knych
May 1, 1996·Alcoholism, Clinical and Experimental Research·W G Mayhan, S P Didion
Feb 1, 1995·Alcoholism, Clinical and Experimental Research·M L AdamsT J Cicero
Jan 25, 2018·Alcoholism, Clinical and Experimental Research·Vishal D NaikJayanth Ramadoss
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