PMID: 15220776Jun 29, 2004Paper

Inhibitory effect of fentanyl on acetylcholine-induced relaxation in rat aorta

Anesthesiology
Ju-Tae SohnYoung-Kyun Chung

Abstract

Previous study has shown that fentanyl attenuates acetylcholine-induced vasorelaxation. The goal of the current in vitro study was to identify the muscarinic receptor subtype that is mainly involved in the fentanyl-induced attenuation of endothelium-dependent relaxation elicited by acetylcholine. The effects of fentanyl and muscarinic receptor antagonists on the acetylcholine concentration-response curve were assessed in aortic vascular smooth muscle ring preparations precontracted with phenylephrine. In the rings pretreated independently with pirenzepine, 4-diphenylacetoxyl-N-methylpiperidine methiodide, and naloxone, acetylcholine concentration-response curves were generated in the presence and absence of fentanyl. The effect of fentanyl on the concentration-response curve for calcium ionophore A23187 was assessed. Fentanyl (0.297 x 10 0.785 x 10 m) attenuated acetylcholine-induced vasorelaxation in ring preparations with or without 10 m naloxone. Pirenzepine (10 to 10 m) and 4-diphenylacetoxyl-N-methylpiperidine methiodide (10 to 10 m) produced a parallel rightward shift in the acetylcholine concentration-response curve. The concentrations (-log M) of pirenzepine and 4-diphenylacetoxyl-N-methylpiperidine methiodide necessary...Continue Reading

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Citations

Jul 15, 2005·Best Practice & Research. Clinical Anaesthesiology·Nina C Weber, Wolfgang Schlack
Nov 24, 2006·American Journal of Therapeutics·Alan D KayeShane Huffman
Jan 15, 2011·Journal of Cardiovascular Pharmacology·Daniele GabrielGisele Zapata-Sudo
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
Feb 27, 2015·Frontiers in Pediatrics·Nils WelcheringCecilia W Lo
Jul 2, 2009·Yonsei Medical Journal·Kyeong-Eon ParkYoung-Kyun Chung
Feb 7, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Wei-Jian WangPeng-Bo Zhang

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