Inhibitory effect of Ferula asafoetida L. (Umbelliferae) on Blastocystis sp. subtype 3 growth in vitro.

Parasitology Research
Hala K El DeebAyman K Abd El-Hameid

Abstract

Asafoetida is an oleo-gum-resin obtained from many Ferula species and frequently used in traditional medicine. The current study aimed to evaluate the activity of asafoetida against the in vitro growth of Blastocystis sp. Asafoetida as powder-form (Ap) and oil-form (Ao) extracts at concentrations of 2, 4, 8, 16, and 20 mg/ml and 5, 10, 25, 40, and 50 mg/ml, respectively were incubated with isolates of Blastocystis sp. subtype 3 for 24, 72, and 144 h and compared to the reference antiprotozoan drug metronidazole at concentrations of 10, 100, and 500 μg/ml. Asafoetida either as Ap or Ao decreased counts and viability of all tested isolates of Blastocystis sp. subtype 3 which was confirmed by microscopy. The degree of the inhibitory effect was dependent on the concentration, form, as well as the time of incubation with asafoetida extracts. The lowest concentrations of Ap and Ao that caused complete (100 %) inhibition of Blastocystis growth and highest (100 %) percentage inhibition of multiplication was 16 and 40 mg/ml, respectively; mean counts at these concentrations either did not differ or decreased significantly when compared to metronidazole control (p < 0.05). Also, the parasites did not resume growth after re-cultivation in...Continue Reading

References

Oct 1, 1996·Clinical Microbiology Reviews·D J Stenzel, P F Boreham
Dec 1, 1996·Journal of Ethnopharmacology·L Q YangK Y Sim
Jun 5, 1999·Tropical Medicine & International Health : TM & IH·K HareshS Saminathan
May 18, 2000·Phytotherapy Research : PTR·M ForceR A Ronzio
Nov 4, 2000·The Journal of Antimicrobial Chemotherapy·V LeméeL Favennec
Nov 6, 2001·The American Journal of Tropical Medicine and Hygiene·Y KanedaH Tachibana
Dec 12, 2001·Phytochemistry·M H Abd El-RazekT Hirata
Jun 6, 2003·Journal of Ethnopharmacology·A Sá-NunesJ M Sforcin
May 1, 1993·Parasitology Today·P J Johnson
May 12, 2006·Parasitology Research·Yiming YanGuifeng Chen
Dec 21, 2006·European Journal of Medicinal Chemistry·S N SuryawanshiSuman Gupta
Jul 14, 2007·Journal of Ethnopharmacology·Fernando CalzadaAmparo Tapia-Contreras
Aug 11, 2007·Bioscience, Biotechnology, and Biochemistry·Mohamed H Abd El-Razek
Feb 6, 2008·Journal of Medicinal Chemistry·Judith M RollingerMichaela Schmidtke
Mar 14, 2008·Parasitology International·Mustafa OzyurtChristen Rune Stensvold
Mar 18, 2009·Parasitology Research·Laetitia SouppartEric Viscogliosi
Aug 21, 2009·Journal of Natural Products·Chia-Lin LeeYang-Chang Wu
Dec 3, 2009·Parasitology Research·Laetitia SouppartEric Viscogliosi
Sep 14, 2010·Journal of Ethnobiology and Ethnomedicine·Kazhila C Chinsembu, Marius Hedimbi
Oct 6, 2010·Parasitology Research·Dina M Abdel HameedNehal Mohamed Zuel-Fakkar
Dec 7, 2010·Journal of Ethnopharmacology·Milad Iranshahy, Mehrdad Iranshahi
Feb 1, 2011·Parasitology Research·Dina Marie Abdel-Hameed, Omayma Mohamed Hassanin
Sep 17, 2011·Parasitology Research·Azucena González-ColomaRafael A Martínez-Díaz
Dec 28, 2011·Parasitology Research·Witabouna Mamidou KonéJennifer Keiser

❮ Previous
Next ❯

Citations

Mar 17, 2015·Journal of Ethnopharmacology·Charlotte Bremer ChristensenAnna K Jäger
Jan 19, 2016·Parasitology International·Özgür KurtMehmet Tanyüksel
Mar 23, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M LepczyńskaJ Korycińska
May 4, 2021·Saudi Journal of Biological Sciences·Shereen F MossallamSafaa I Khedr

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.