Inhibitory effect of GABAergic drugs in cocaine-induced genital reflexes in paradoxical sleep-deprived male rats

Pharmacology, Biochemistry, and Behavior
M L Andersen, S Tufik

Abstract

The aim of this study was to seek whether GABAergic drugs were involved in the action of cocaine on spontaneous genital reflexes (penile erection-PE, and ejaculation-EJ) of paradoxical sleep-deprived (PSD) male rats. After a 4-day period of PSD, each group was administered with GABAergic drugs 1 h prior to cocaine and placed in observation cages. The administration of gamma-aminobutyric acid (GABA)-A agonist (muscimol, 2 and 3 mg/kg sc) reduced the number of animals displaying PE, whereas all doses tested of muscimol and bicuculline significantly reduced the frequency of PE. Pretreatment with the lower doses of GABA-B antagonist, phaclofen (1 and 2 mg/kg sc), also significantly reduced the percentage of rats showing PE; however, after the higher dose injection, the proportion of animals with PE was similar to those seen after vehicle pretreatment. Both GABA-B agonist and antagonist significantly reduced the PE frequency for all doses used compared with the vehicle group. There were no significant differences between control and GABA-A drugs in EJ behavior, whereas phaclofen 2 mg/kg pretreatment increased the ejaculatory latency. These data show that GABAergic compounds inhibited PE in male PSD rats suggesting that this inhibiti...Continue Reading

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Feb 11, 2003·Physiology & Behavior·Monica L AndersenSergio Tufik
Feb 7, 2004·Journal of Neuroendocrinology·M Levy AndersenS Tufik
Mar 24, 2004·Experimental Gerontology·Monica Levy AndersenSergio Tufik

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Citations

Feb 5, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Malinalli Brianza-PadillaGonzalo Vázquez-Palacios
Jan 21, 2006·The Journal of Sexual Medicine·Francesco Montorsi, Michael Oettel
Jun 15, 2007·Research in Veterinary Science·Patricia S B Rodrigues-AlvesHelenice de S Spinosa
Jan 16, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Monica L AndersenSergio Tufik
Feb 6, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Monica L AndersenSergio Tufik
Dec 8, 2004·Pharmacology, Biochemistry, and Behavior·M L AndersenS Tufik

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