PMID: 15329590Aug 27, 2004Paper

Inhibitory effect of glucocorticoids on human-cloned 5-hydroxytryptamine3A receptor expressed in xenopus oocytes

Anesthesiology
Takahiro SuzukiIchiro Uchida

Abstract

Methylprednisolone, dexamethasone, and other glucocorticoids have been found effective against nausea and vomiting induced by chemotherapy and surgery. Although the specific 5-hydroxytriptamine3 (5-HT3) receptor antagonists such as ondansetron and ramosetron are used as antiemetics, reports show that the use of 5-HT3 receptor antagonists with some glucocorticoids brings additional effects. Glucocorticoids are reported to be antiemetic. The effect of glucocorticoids on 5-HT3 receptor, however, has not been well characterized. This study was designed to examine whether dexamethasone and methylprednisolone had direct effects on human-cloned 5-HT3A receptor expressed in Xenopus oocytes. Homomeric human-cloned 5-HT3A receptor was expressed in Xenopus oocytes. The authors used the two-electrode voltage-clamping technique to study the effect of methylprednisolone and dexamethasone on 5-HT-induced current. Both dexamethasone and methylprednisolone concentration-dependently attenuated 5-HT-induced current. Dexamethasone inhibited 2 microm 5-HT-induced current, which was equivalent to EC30 concentration for 5-HT3A receptor, with an inhibitory concentration 50% of 5.29 +/- 1.02 microm. Methylprednisolone inhibited 2 microm 5-HT-induced cu...Continue Reading

References

Jun 1, 1979·Journal of Pharmacokinetics and Biopharmaceutics·S E TsueiW G McBride
Jan 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M G KrisS Groshen
Apr 1, 1980·Gynecologic Oncology·W M RichP J DiSaia
Jun 1, 1994·Journal of Neuroendocrinology·M Wong, R L Moss
Jan 1, 1995·Annual Review of Physiology·M B Jackson, J L Yakel
Mar 1, 1995·Trends in Neurosciences·M O Ortells, G G Lunt
Mar 1, 1994·Neuropharmacology·F G Boess, I L Martin
May 1, 1994·Cancer Practice·R J Ignoffo
Sep 1, 1993·Neuron·R RupprechtF Holsboer
Jun 1, 1996·Oncology·H J Schmoll, J Casper
Sep 5, 1998·Brain Research·N YaghoubiD H Farb

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Citations

Feb 6, 2014·European Journal of Pharmacology·Charles C HornJohn P Williams
Nov 5, 2013·European Journal of Pharmacology·Chin-Chen ChuJhi-Joung Wang
May 6, 2014·Experimental Brain Research·Erin M RockLinda A Parker
Feb 6, 2013·Trends in Pharmacological Sciences·Andrew J Thompson
Jul 14, 2010·Pharmacology & Therapeutics·Jutta WalstabBeate Niesler
May 10, 2005·European Journal of Pharmacology·Gábor MaksayGyula Bugovics
Dec 31, 2010·Biophysical Journal·Jeremías CorradiCecilia Bouzat
Jun 3, 2015·Neuro-oncology Practice·Patrick RothMichael Weller
Jan 20, 2021·The Oncologist·Tobias JanowitzRobert H Vonderheide
Nov 17, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S M Grunberg
May 8, 2021·The Annals of Thoracic Surgery·Xiuyan LiJunchao Zhu

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