Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Koichiro MoriNorimichi Nakahata

Abstract

Platelet aggregation in the blood vessel causes thrombosis. Therefore, inhibitors of platelet aggregation promise to be preventive or therapeutic agents of various vascular diseases, including myocardial infarction and stroke. In the present study, we found that hericenone B had a strong anti-platelet activity and it might be a novel compound for antithrombotic therapy possessing a novel mechanism. Prior to this study, we examined anti-platelet aggregation activity of ethanol extracts of several species of mushrooms, and found that extract of Hericium erinaceus potently inhibited platelet aggregation induced by collagen. Therefore, we first fractionated the ethanol extract of H. erinaceus to identify the active substances. The anti-platelet activity of each fraction was determined using washed rabbit platelets. As a result, an active component was isolated and identified as hericenone B. Hericenone B selectively inhibited collagen-induced platelet aggregation, but it did not suppress the aggregation induced by U46619 (TXA₂ analogue), ADP, thrombin, or adrenaline. Furthermore, hericenone B did not inhibit arachidonic acid- or convulxin (GPVI agonist)-induced platelet aggregation. Therefore, hericenone B was considered to block c...Continue Reading

References

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Sep 28, 2007·Current Pharmaceutical Design·Kenneth J Clemetson, Jeannine M Clemetson
Sep 2, 2008·Biological & Pharmaceutical Bulletin·Koichiro MoriNorimichi Nakahata

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Citations

Sep 3, 2013·Vascular Pharmacology·Gemma Vilahur, Lina Badimon
Jul 30, 2014·Applied Microbiology and Biotechnology·Shengjuan JiangQiang Zhang
Jun 6, 2013·Journal of Complementary & Integrative Medicine·Md Asaduzzaman KhanMohammad Mijanur Rahman
Aug 16, 2019·Biomedical Research·Yuusuke SaitsuKoichiro Ohnuki
Aug 23, 2016·Biomedical Research·Shoko FurutaKuniyoshi Shimizu
Jan 26, 2021·The Journal of Organic Chemistry·Shoji KobayashiKaoru Nagai
Jun 3, 2021·Journal of Fungi·Allen Grace NiegoKevin D Hyde
Jul 27, 2021·Organic & Biomolecular Chemistry·Huifang LaiDaijun Zha

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