PMID: 2384623Aug 1, 1990

Inhibitory effect of human plasma and saliva on co-aggregation between Bacteroides gingivalis and Streptococcus mitis

Journal of Dental Research
H NagataA Tsunemitsu

Abstract

The effect of human plasma and saliva on co-aggregation between Bacteroides gingivalis and Streptococcus mitis was studied by means of a turbidimetric assay. The co-aggregation activity was obtained from the maximum slope of the absorbance vs. time curve. Its dependence on pH, temperature, and ionic strength was examined, and the number of Bacteroides cells in relation to the number of Streptococcus cells resulting in optimal co-aggregation was established. Co-aggregation inhibition experiments showed that the co-aggregation activity was inhibited by l-arginine and l-lysine, although the activity was unaffected by the sugars tested. Human plasma and saliva were able to inhibit the co-aggregation in a dose-dependent reaction. Plasma exhibited the most potent inhibitory activity in these fluids. Fibrinogen was the most potent inhibitor of the plasma-derived proteins tested. These data suggest the possibility that the oral fluids may modulate the attachment of B. gingivalis to Gram-positive bacteria in periodontal pockets.

References

Dec 1, 1975·Journal of Oral Pathology·T EricsonH Wedel
Jan 1, 1986·Journal of Clinical Periodontology·L Sandholm
Dec 1, 1986·Infection and Immunity·M S LantzM Höök
Apr 13, 1968·Nature·H R Baumgartner, G V Born
Jan 1, 1983·Medical Microbiology and Immunology·C LämmlerH Blobel
Jan 1, 1984·Infection and Immunity·D MalamudR Goldman
Aug 1, 1984·Journal of Medical Microbiology·J CarlssonG K Sundqvist
Jul 1, 1963·Journal of Dental Research·H J KEENE

Citations

Jan 12, 2001·Oral Microbiology and Immunology·Richard J Lamont, H F Jenkinson
Jan 1, 1994·Microbiology and Immunology·A KamaguchiK Inomata
Aug 1, 1992·Oral Microbiology and Immunology·Richard J LamontB Rosan
Oct 11, 1992·Oral Microbiology and Immunology·K S George, W A Falkler
Feb 1, 1994·Oral Microbiology and Immunology·R J Skopek, W F Liljemark
Feb 1, 1996·Oral Microbiology and Immunology·E S YaoA Weinberg
Nov 3, 2010·FEMS Immunology and Medical Microbiology·Rieko ItoKatsuji Okuda
Aug 27, 2003·Journal of Dental Research·J GroeninkA V Nieuw Amerongen
Jul 18, 2002·European Journal of Oral Sciences·Masaru SatoHiroshi Takeuchi
Jan 1, 1991·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·A L Boskey
Dec 23, 2004·Oral Microbiology and Immunology·A SharmaH K Kuramitsu

Related Concepts

Bacterial Adhesion
Bacteroides
Serum Proteins
Hydrogen-Ion Concentration
Turbidimetry
Fresh Frozen Plasma
Saliva
Streptococcus

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.