Inhibitory effect of IL-6-induced neuroendocrine cells on prostate cancer cell proliferation

The Prostate
Qingcai WangJacek Pinski

Abstract

The role of increased neuroendocrine (NE) differentiation in prostate cancer (PCA) is not well understood. Long-term exposure of the prostate cancer cell line LNCaP to high concentrations of the cytokine interleukin-6 (IL-6) results in permanent transdifferentiation of these cells into a NE phenotype. In this study, we evaluated the effect of IL-6-induced NE cells on the growth of the PCA cell lines LNCaP, PC-3, and DU-145 in vitro. Co-culture of NE cells with PCA cells significantly inhibited DNA synthesis in all three PCA cell lines by 30-90% compared to controls. NE cell co-culture resulted in an increased percentage of PCA cells arrested in the S-phase of cell cycle and PCA cell apoptosis. Our results imply that NE cells suppress the proliferation of surrounding PCA cells by release of inhibitory factors.

References

Aug 26, 1998·The Biochemical Journal·P C HeinrichL Graeve
Apr 30, 1999·The Prostate·P A Abrahamsson
Apr 20, 2001·Cytokine & Growth Factor Reviews·P C SmithE T Keller
Nov 15, 2002·Molecular and Cellular Endocrinology·Zoran CuligAlfred Hobisch
Mar 19, 2003·Lancet·Henrik Grönberg

❮ Previous
Next ❯

Citations

Mar 11, 2006·Nature Clinical Practice. Urology·Susan F Slovin
May 10, 2006·Prostate Cancer and Prostatic Diseases·Y Liu
May 23, 2012·Clinical Genitourinary Cancer·Chadi Nabhan, Daniel P Petrylak
May 3, 2006·The Prostate·Jacek PinskiPeter V Danenberg
Oct 2, 2009·International Journal of Cancer. Journal International Du Cancer·Helena TassidisAnette Gjörloff Wingren
Oct 11, 2016·Chemico-biological Interactions·Bhumika Wadhwa, Rashmi Dumbre
Mar 19, 2008·Molecular Cancer Therapeutics·Daniel E Frigo, Donald P McDonnell
Jun 13, 2015·Cancer Research·Marianna CerasuoloAlessia Ligresti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis