Inhibitory effect of isoliquiritin, a compound in licorice root, on angiogenesis in vivo and tube formation in vitro

Biological & Pharmaceutical Bulletin
S KobayashiM Kimura

Abstract

A water extract of licorice root inhibits granuloma angiogenesis in adjuvant-induced chronic inflammation (Phytother. Res., 5, 195. 1991). The present study has investigated the effects of licorice-derived compounds on granuloma angiogenesis. Isoliquiritin (0.31-3.1 mg/kg), a licorice-derived flavonoid, inhibited the carmine content of granuloma tissue 50-fold greater than licorice extract. Glyeyrrhizin (20-80 mg/kg), a licorice-derived saponin, inhibited carmine content with a weak potency. The licorice extract (0.01-1 mg/ml) also inhibited tube formation from vascular endothelial cells in a concentration-dependent manner. From the chemical structure-activities of used licorice-derived flavonoids (0.1-100 microM), their potencies for anti-tube formation were in the order isoliquiritigenin > isoliquiritin > liquiritigenin > isoliquiritin-apioside. Glycyrrhizin (0.1-100 microM) and glycyrrhetinic acid (0.1-10 microM) increased tube formation. A glycyrrhizin (82 micrograms/ml)-induced increase in tube formation was inhibited by isoliquiritin. The combined effect of a mixture of 82 micrograms/ml glycyrrhizin and 4.2 micrograms/ml isoliquiritin, a similar concentration ratio to their yield ratio in the licorice extract, corresponde...Continue Reading

Citations

Apr 12, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Soojin ParkHyunsu Bae
Nov 23, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Rashmi GaurRajendra Singh Bhakuni
Apr 25, 2009·BMC Cell Biology·Sajjad HussainJohn Gaffney
Apr 13, 2011·Genes & Nutrition·Barbora OrlikovaMarc Diederich
Jun 24, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Parivash SeyfiAmir Kiani
Dec 23, 2008·Journal of Ethnopharmacology·Rui-Xin ZhangLixing Lao
Jun 3, 2011·Fundamental & Clinical Pharmacology·Yan GuanQiang-Min Xie
Apr 28, 2012·Biochemical and Biophysical Research Communications·Eun-Ju YangDong-Seok Lee
May 16, 2006·Trends in Pharmacological Sciences·Tai-Ping FanRicky N S Wong
Jan 19, 2013·Expert Opinion on Therapeutic Targets·Kai-Lee WangPaulus S Wang
Jan 4, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Suzuro HitomiKiyotoshi Inenaga
Sep 2, 2004·Biological & Pharmaceutical Bulletin·Shinjiro KobayashiSeikoh Horiuchi
Aug 7, 1997·International Journal of Cancer. Journal International Du Cancer·S UshiroM Kuwano
Aug 17, 2000·The Journal of the Royal Society for the Promotion of Health·A Olukoga, D Donaldson
May 9, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Supaluk PrachayasittikulVirapong Prachayasittikul
Feb 26, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jianjun LuoMeiying Hu
May 1, 2008·Phytotherapy Research : PTR·Marjan Nassiri Asl, Hossein Hosseinzadeh
May 9, 2014·Biological & Pharmaceutical Bulletin·Zheng-zheng GuoSheng-li Wei
Jul 3, 2018·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Wenjing WangYing Zhan
Jan 8, 2011·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Ao-Xue WangLing Yang
Aug 4, 2001·Cancer Letters·K IguraK Kaji
Jun 10, 2010·Journal of Agricultural and Food Chemistry·Chun-Hsu PanChieh-Hsi Wu
Jan 1, 2014·Journal of Agricultural and Food Chemistry·Tzu-Chien KaoGow-Chin Yen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.