PMID: 6112931Feb 1, 1981Paper

Inhibitory effect of KWD 2131, terbutaline, and DSCG on the immediate and late allergen-induced bronchoconstriction

Allergy
B HegardtM Van der Straeten

Abstract

Beta-adrenoceptor stimulants exhibit both bronchodilating and anti-allergic activities. KWD 2131 is a new beta-agonist with preferably anti allergic property. In an earlier study, nebulized KWD 2131 in a non-bronchodilating dose (0.25--0.50 mg) did not give significant protection against immediate reaction. The present study evaluated whether an increased nebulized dose of the new compound (5 mg) could protect against either immediate and/or late responses. The response was compared with a nebulized dose of terbutaline (5 mg) and with twice the recommended dose DSCG (40 mg). The study included 10 patients with known allergic asthma. It was designed as a single-blind cross-over trial with randomized allocation of the drugs. Lung functions were measured spirometrically and by body-plethysmograph; flow volume curves were drawn. KWD 2131 gave no significant protection against immediate reaction. Both terbutaline and DSCG did so, terbutaline being more efficient. Contrary to the beta-agonists, DSCG also gave protection against late response.

References

Oct 27, 1979·British Medical Journal·J T Chung, R S Jones
Jul 1, 1976·The Journal of Allergy and Clinical Immunology·T NakazawaS Kobayashi
Aug 23, 1976·JAMA : the Journal of the American Medical Association·U Y RyoR G Townley
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Citations

Jan 1, 1990·Pharmacology & Therapeutics·R G GoldieK M Lulich
Nov 30, 1989·The New England Journal of Medicine·P J Barnes
Apr 27, 2004·Immunopharmacology and Immunotoxicology·Shung-Te KaoJaung-Geng Lin
Sep 1, 1987·The American Review of Respiratory Disease·P M O'ByrneF E Hargreave
Oct 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G Di LorenzoG Barbagallo Sangiorgi
Oct 31, 2009·International Immunopharmacology·Young Woon JangChang Jong Kim
Jul 1, 1990·Respiratory Medicine·S R Durham
Sep 12, 2007·Allergy·L-P BouletUNKNOWN Clinical Investigative Collaboration, Canadian Network of Centers of Excellence AllerGen
Jul 1, 1985·Clinical Allergy·M K Church, J O Warner
Mar 1, 1987·Clinical Allergy·A B Kay
Nov 1, 1989·Statistics in Medicine·S J Senn
Jan 1, 1988·The Journal of Allergy and Clinical Immunology·P M O'Byrne
Jan 1, 1987·Drug Intelligence & Clinical Pharmacy·S Murphy, H W Kelly

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