PMID: 9522178Apr 2, 1998

Inhibitory effect of MCI-186, a free radical scavenger, on cerebral ischemia following rat middle cerebral artery occlusion

General Pharmacology
A MizunoM Nakashima

Abstract

1. In this study, we investigated the effect of a radical scavenger, MCI-186 (3-methyl-1-phenyl-2-pyrazolin-5-one), on cerebral damage induced by rat middle cerebral artery (MCA) occlusion, and further measured the hydroxyl radical level at the ischemic border zone using a microdialysis technique. 2. MCI-186, at a dose of 3 mg/kg per 30 min, was administered as a continuous infusion two times for 30 min, starting 20 min and then 80 min after Rose Bengal injection. 3. MCI-186 significantly (P < 0.05) reduced size of cerebral damage 24 hr after MCA occlusion and significantly (P < 0.05) reduced hydroxyl radical level.

References

Sep 17, 2005·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Kenichi HashizumeRyohei Yozu
Dec 11, 2007·Molecular Neurobiology·Venkata Prasuja NakkaRam Raghubir
Mar 18, 2009·Neuroscience Bulletin·Ji-Xiang ChenDan-Xia Huang
Dec 7, 2002·Life Sciences·Kyuya Kogure
Jun 11, 2003·Journal of Gastroenterology and Hepatology·Shinchiro TadaHiromasa Ishii
Feb 6, 2004·Chemical & Pharmaceutical Bulletin·Shinji AbeToshiaki Tamaki
Mar 31, 2004·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Toshiaki WatanabeAkihiro Tobe
Jun 14, 2002·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Masahiko Tanaka
Apr 6, 2006·Internal Medicine·Yuichiro InatomiMakoto Uchino
Jul 28, 2012·International Journal of Molecular Sciences·Rosivaldo S BorgesAlbérico B F da Silva
May 31, 2011·Best Practice & Research. Clinical Anaesthesiology·Thorsten R Doeppner, Dirk M Hermann
Mar 24, 2010·Brain Research·Koji OsukaMasakazu Takayasu
Apr 22, 2008·European Journal of Pharmacology·Tomohiro NakamuraAkinori Akaike
Feb 18, 2005·Acta Anaesthesiologica Scandinavica·T Nishiyama, M Ogawa
May 15, 2007·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Masanori AbeKoichi Matsumoto
May 20, 2008·Cardiovascular Therapeutics·Toshiaki WatanabeSatoru Todo
Jan 29, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masanori Hirano
Jul 27, 2005·Free Radical Biology & Medicine·Isabelle MargaillDominique Lerouet
Oct 14, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Katsunobu TakenakaKatsuhiko Hayashi
Jul 25, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Hidetoshi NakamotoYoshikazu Okada
Dec 3, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Hanbing ShangWeiguo Zhao
Jun 18, 2016·Expert Review of Neurotherapeutics·Yu-Ichi NotoMatthew C Kiernan

Citations

Jan 1, 1991·Free Radical Biology & Medicine·B HalliwellM Ingelman-Sundberg
Sep 1, 1991·Stroke; a Journal of Cerebral Circulation·N MatsumiyaR J Traystman
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·H KinouchiP H Chan
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C N OliverR A Floyd
Sep 1, 1989·Stroke; a Journal of Cerebral Circulation·H NishiA Ishibashi
Nov 1, 1989·Stroke; a Journal of Cerebral Circulation·R OishiK Saeki
Apr 1, 1988·Stroke; a Journal of Cerebral Circulation·K AbeK Kogure
Jul 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T WatanabeS Murota
May 26, 1988·Neuroscience Letters·W CaoM Chevion
Jan 1, 1983·Annals of Neurology·M E Raichle
Nov 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y MatsuoK Kogure
Jan 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T MorimotoM D Ginsberg
May 1, 1996·Free Radical Research·U MinhazH Nakazawa
Sep 1, 1996·Stroke; a Journal of Cerebral Circulation·Kazuo UmemuraM Nakashima

Related Concepts

2-pyrocatechuic acid, sodium salt
Phenylmethylpyrazolone
Hydroxyl Radical
Brain
Free Radicals
MCI 186
Closure by Clamp
Pyramidone
Free Radical Scavengers
Obstruction

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.