Inhibitory effect of melatonin on diquat-induced lipid peroxidation in vivo as assessed by the measurement of F2-isoprostanes

Journal of Pineal Research
Lifu ZhangRussel J Reiter

Abstract

Melatonin is a powerful antioxidant and free radical scavenger. A large body of in vivo and in vitro evidence shows that melatonin effectively inhibits membrane lipid peroxidation; this damage was based on the measurement of malondialdehyde and/or 4-hydroxynonenal levels. In the current study, for the first time using a more sensitive and specific biomarker, i.e. F2-isoprostanes, we investigate the effect of melatonin on diquat-induced lipid peroxidation in Fischer 344 rats. When diquat (40 mg/kg body weight) was intraperitoneally injected into rats, the levels of liver F2-isoprostanes were significantly increased at 1, 3, and 6 hr while plasma free F2-isoprostanes concentrations were augmented at 3, 6, and 12 hr after administration of the toxin. In addition, the plasma alanine aminotransferase activity level was measured as a parameter of hepatoxicity; the activity of this enzyme was augmented at 3, 6, and 12 hr after diquat administration when compared with levels of this constituent in untreated control rats. Pretreatment with melatonin (20 mg/kg) 30 min before diquat administration resulted in a significant reduction in both tissue and plasma F2-isoprostanes levels, and plasma alanine aminotransferase activity. These findi...Continue Reading

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Citations

Jun 2, 2007·Journal of Periodontology·Antonio CutandoRussel J Reiter
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Aug 9, 2016·Journal of Pineal Research·Russel J ReiterLilian Qin
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Aug 22, 2018·International Journal of Molecular Sciences·Russel J ReiterDario Acuna-Castroviejo
Nov 17, 2017·Oxidative Medicine and Cellular Longevity·Karolina Szewczyk-GolecAlina Woźniak
Jun 7, 2008·Experimental Biology and Medicine·Ercan GöcgeldiMetin Hasde
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