PMID: 10606005Dec 22, 1999Paper

Inhibitory effect of natural and environmental estrogens on thymic hormone production in thymus epithelial cell culture

International Journal of Immunopharmacology
K SakabeF Kayama

Abstract

The present study was carried out to assess the direct effect of natural estrogen and environmental estrogens on thymus epithelial cell (TEC) production/secretion of the thymic hormone thymosin-alpha 1 by using the technique of quantitative high-performance liquid chromatography. The presence of estrogen receptors in the TECs was also investigated. Murine TECs were cultured in the experimental DMEM medium containing various concentrations of natural or environmental estrogens, which was followed by determining the production of thymosin-alpha 1. The production of thymosin-alpha 1 by TECs was significantly inhibited by increasing concentrations of 17beta-estradiol (natural estrogen) over 3 x 10(-11) M, genistein (phytoestrogen) over 3 x 10(-9) M, coumestrol (phytoestrogen) over 3 x 10(-9) M, alpha-zearalanol (livestock anabolic) over 3 x 10(-7) and bisphenol-A (plastic) over 3 x 10(-6) M. Small amounts of estrogen receptor were present in the TECs. The above results clearly indicate that natural and environmental estrogens directly modulate TECs to produce thymic hormone probably through an estrogen receptor mechanism. Furthermore, our finding may be useful for evaluating biological effects of chemicals with estrogenic activity.

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Citations

Jul 18, 2002·Toxicology Letters·Humitoshi SakazakiKatsuhiko Nakamuro
Sep 1, 2003·Environmental Toxicology and Pharmacology·Takayuki NegishiYasuhiro Yoshikawa
Jan 28, 2004·Bioscience, Biotechnology, and Biochemistry·Masao GotoMitsuru Yoshida
Jul 14, 2010·International Journal of Environmental Research and Public Health·Kenneth NdebelePaul B Tchounwou
Sep 11, 2007·Bioscience, Biotechnology, and Biochemistry·Masao GotoHiroshi Shinmoto
Jul 22, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Nadzieja Drela
Jul 14, 2007·Reproductive Toxicology·Yelena B WetherillScott M Belcher
Feb 18, 2006·Laboratory Investigation; a Journal of Technical Methods and Pathology·Frank TraubHarald Tammen
Oct 6, 2005·Annals of Medicine·Cesare R SirtoriStuart K Johnson
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Hironori IshibashiHironobu Sasano
May 6, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Stéphane PilletDaniel G Cyr

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