Inhibitory effect of N,N-didesmethylgrossularine-1 on inflammatory cytokine production in lipopolysaccharide-stimulated RAW 264.7 cells.

Marine Drugs
Taiko OdaMichio Namikoshi

Abstract

N,N-Didesmethylgrossularine-1 (DDMG-1), a compound with a rare alpha-carboline structure, was isolated from an Indonesian ascidian Polycarpa aurata as responsible for the observed inhibitory activity against TNF-alpha production in lipopolysaccharide-stimulated murine macrophage-like RAW264.7 cells. DDMG-1 inhibited the mRNA level of mTNF-alpha, IkappaB-alpha degradation, and binding of NF-kappaB to the target DNA site in LPS-stimulated RAW 264.7 cells. Moreover, DDMG-1 had an inhibitory effect on the production of IL-8, which is produced in CD14(+)-THP-1 cells stimulated by LPS. DDMG-1 is thus a promising drug candidate lead compound for the treatment of chronic inflammatory diseases, such as rheumatoid arthritis.

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Citations

Jan 21, 2016·Journal of Biomedical Science·Hsiao-Chieh HuangPo-Wu Gean
Apr 16, 2013·Organic Letters·Cong-Dat PhamPeter Proksch
Apr 8, 2011·Natural Product Reports·Zhong Jin
Feb 6, 2017·Immunopharmacology and Immunotoxicology·Liza Merly, Sylvia L Smith
Dec 17, 2018·Carbohydrate Polymers·Haris LeelayuwapanSiwarutt Boonyarattanakalin

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Methods Mentioned

BETA
NMR
ELISA
PCR
X-ray
electrophoresis

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