PMID: 7544471Apr 14, 1995Paper

Inhibitory effect of ODN, a naturally occurring processing product of diazepam binding inhibitor, on secretagogues-induced insulin secretion

Regulatory Peptides
P De StefanisA Guidotti

Abstract

Diazepam binding inhibitor (DBI1-86) is a peptide that is present in large amounts in the intestine and pancreas and which inhibits glucose-stimulated insulin release from both perfused pancreas and isolated islets in low nanomolar concentrations. Here, DBI33-50 (also known as ODN, octadecaneuropeptide), one of the naturally occurring processing products of DBI1-86, and certain synthetic modified derivatives, have been shown to inhibit glucose and glibenclamide-stimulated insulin secretion from isolated rat islets and glibenclamide-stimulated insulin secretion from hamster-insulinoma (HIT-T15) beta-cell line. DBI17-50 (TTN; triakontatetraneuropeptide), another prominent processing product of DBI, had no effect. The 50% inhibitory concentration (IC50) for the effect of ODN on insulin secretion induced by 8.3 of 16.7 mM glucose was approximately the same: 5 to 6 nM. Moreover, ODN inhibited insulin release induced by 0.01 or 1 microM glibenclamide with a similar IC50 (8 to 10 nM) in both isolated pancreatic islets and in HIT-T15 beta-cells. At concentration up to 1 microM, ODN had no effect on insulin secretion induced by PACAP (pituitary adenylate cyclase polypeptide), BAYK 8644 (methyl-(1,4-dihydro-2,6-dimethyl-3-nitro-4,2-trifl...Continue Reading

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Citations

Sep 1, 1996·Lipids·R E GossettF Schroeder
Sep 13, 2001·Molecular Biology of the Cell·N IranfarW F Loomis
Oct 10, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gregory G MartinFriedhelm Schroeder
Oct 2, 2013·Biochimica Et Biophysica Acta·Maria BloksgaardSusanne Mandrup
Jun 12, 2010·The Journal of Nutritional Biochemistry·Barbara P AtshavesFriedhelm Schroeder
Jul 10, 2019·Pharmacology & Therapeutics·Marie-Christine TononJérôme Leprince

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