Inhibitory effect of Patrinia scabiosaefolia on acute pancreatitis

World Journal of Gastroenterology : WJG
Sang-Wan SeoSung-Joo Park

Abstract

To investigate the effect of Patrinia scabiosaefolia (PS) on the cholecystokinin (CCK) octapeptide-induced acute pancreatitis (AP) in rats. Wistar rats weighing 240-260 g were divided into three groups: (1) Normal saline-treated group; (2) treatment with PS at 100 mg/kg group, in which PS was administered orally, followed by subcutaneous administration of 75 microg/kg CCK octapeptide three times after 1, 3 and 5 h, and this whole procedure was repeated for 5 d; (3) treatment with saline group, in which the protocols were the same as in treatment group with PS. We determined the pancreatic weight/body weight ratio, the levels of pancreatic HSP60, HSP72 and the secretion of pro-inflammatory cytokines. Repeated CCK octapeptide treatment resulted in the typical laboratory findings of experimentally induced pancreatitis. PS reduced the pancreatic weight/body weight ratio, the levels of serum amylase and lipase, and inhibited expressions of pro-inflammatory cytokines in the CCK octapeptide-induced AP. Furthermore, PS pretreatment increased the pancreatic levels of HSP60 and HSP72. Pretreatment with PS has an anti-inflammatory effect on CCK octapeptide-induced AP.

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Citations

Jul 16, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Wei ZouYichu Nie
Oct 1, 2015·Current Microbiology·Heejeong LeeDong Gun Lee
Mar 16, 2017·Phytotherapy Research : PTR·Pratibha AnchiChandraiah Godugu
Jun 10, 2017·The American Journal of Chinese Medicine·Xirui HeLinhong Huang

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