PMID: 12753366May 20, 2003Paper

Inhibitory effect of procyanidin oligomer from elm cortex on the matrix metalloproteinases and proteases of periodontopathogens

Journal of Periodontal Research
Si-Eun SongChong-Kwan Kim

Abstract

The purpose of this study was to evaluate a partially purified extract (elm extract) from the Ulmi cortex (Ulmi macrocarpa Hance) and its active ingredient, a mix of procyanidin oligomers (3 to 12 flavan-3-ol monomers, an average molecular weight of 1,518 with an average polymerization degree of 5.3) for a possible inhibitory effect against proteases. Host-derived matrix metalloproteinases (MMPs) and bacterial proteases play important roles in the gingival tissue destruction that is a characteristic of periodontitis. The inhibitors of these proteases may be developed into therapeutic agents against periodontitis. The inhibitory effects were assessed by gelatin zymography. The MMPs tested were originated from the gingival crevicular fluid (GCF) of adult periodontitis patients and from the conditioned media of cultured periodontal ligament (PDL) cells, which provided the proMMP-2 and activated MMP-2 when treated with a periodontopathogen, Treponema lecithinolyticum. Bacterial enzymes tested were secreted forms from two major periodontopathogens, Porphyromonas gingivalis and Treponema denticola. In addition, the inhibitory effects on trypsin-like enzymes from these two periodontopathogens were assayed by the n-benzoyl-DL-arginine-...Continue Reading

References

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Citations

Jul 30, 2008·Critical Reviews in Food Science and Nutrition·C BodetE I Weiss
Jan 14, 2011·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Moon-Moo Kim
Nov 10, 2010·Journal of Oral Rehabilitation·P H dos SantosA K B Bedran-Russo
Aug 6, 2013·Journal of Esthetic and Restorative Dentistry : Official Publication of the American Academy of Esthetic Dentistry ... [et Al.]·Jorge PerdigãoAlessandro D Loguercio
Dec 10, 2009·Journal of Clinical Periodontology·Andrea M MarcacciniRaquel F Gerlach
May 3, 2011·Journal of Biomechanics·Paulo Henrique Dos SantosAna Karina Bedran-Russo
Dec 24, 2005·Journal of Dental Research·C Chaussain-MillerS Menashi
Nov 5, 2008·Biological & Pharmaceutical Bulletin·Kwang-Seok OhByung Ho Lee
Feb 14, 2006·The Journal of Antimicrobial Chemotherapy·Charles BodetDaniel Grenier
Feb 13, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dimitris MichailidisAlexios Léandros Skaltsounis
May 24, 2019·Journal of Agricultural and Food Chemistry·Silvia MolinoMariano Enrique Fernandez Miyakawa

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