Inhibitory effect of Pulsatilla chinensis polysaccharides on glioma

International Journal of Biological Macromolecules
Fenggang ZhouLizhuang Yang

Abstract

Malignant glioma is a very devastating disease. Conventional surgery, radio-and chemotherapy are of limited benefit to improve the cure of patients with malignant astrocytomas. In this research, we evaluated the inhibitory effect of Pulsatilla chinensis polysaccharides (PCPS) on glioma in vivo and in vitro. PCPS had a significant anti-proliferative effect on C6 glioma in vitro assay. Meanwhile a remarkable inhibitory effect PCPS on the growth of C6 glioma and prolongation of life survival could be observed in vivo, comparable to carmustine (BCNU) administration. Moreover PCPS treatment to tumor bearing mice could not only decrease the body weight loss, but also elevate the thymus and spleen indices. In addition, PCPS administration to tumor bearing mice could relieve the liver and kidney damage with decreased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and urea, and enhance superoxide dismutase (SOD) and catalase (CAT) enzyme activities with lower MDA levels in the plasma of tumor bearing mice. The above data proved that PCPS had strong antitumor activity and could be considered as a possible candidate drugs for the glioma therapy.

Citations

Oct 2, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lei DuYi-Qiao Xing
Sep 5, 2012·Carbohydrate Polymers·Aizhen ZongFengshan Wang
Dec 19, 2012·International Journal of Biological Macromolecules·Tong LiuBaogang Liu
Feb 22, 2014·International Journal of Biological Macromolecules·Xuejun LiXianrui Yuan
Feb 3, 2018·International Journal of Biological Macromolecules·Sairong FanXiaoming Chen

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