PMID: 8595632Nov 1, 1995Paper

Inhibitory effect of pyruvate on release of glutathione and swelling of rat heart mitochondria

Cardiovascular Research
A BindoliM P Rigobello

Abstract

Pyruvate prevents the permeability transition of rat heart mitochondria induced by the system calcium ions + phosphate or by the dithiol reagent phenylarsenoxide and measured as swelling. Since swelling induced by the latter is relieved by the dithiol 2,3-dimercaptopropanol (BAL), it is inferred that the effect of pyruvate might be mediated by the reduction of lipoic acid. In isolated mitochondria, pyruvate also exerts a protective effect when calcium + phosphate-induced swelling is exacerbated by hypoxic conditions. These results agree with our previous observations that pyruvate markedly prevents the loss of cytosolic and mitochondrial glutathione after ischemia or ischemia followed by reperfusion.

Citations

Oct 8, 1999·European Journal of Drug Metabolism and Pharmacokinetics·G Wu
Feb 11, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Miaomiao JiangZheng Li
Oct 4, 2006·Free Radical Biology & Medicine·Irina G SavaAntonio Toninello

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