Inhibitory effect of ramosetron on corticotropin releasing factor- and soybean oil-induced delays in gastric emptying in rats

Journal of Gastroenterology and Hepatology
Takuya HirataNobuo Seki

Abstract

Symptoms of functional dyspepsia (FD) are highly prevalent in patients with irritable bowel syndrome (IBS). However, the effects of therapeutic agents for IBS on the pathophysiology of FD are unclear. In this study, therefore, we examined the effects of ramosetron, a serotonin 5-HT(3) receptor antagonist, on corticotropin releasing factor (CRF)- and soybean oil-induced delays in gastric emptying of rats, in comparison with anti-diarrheal agent and spasmolytics. The involvement of 5-HT and the 5-HT(3) receptor in delayed gastric emptying was also evaluated. Corticotropin releasing factor was administered intravenously to rats 10min before oral administration of 0.05% phenol red solution, and the amount remaining in the stomach was measured after 30min. Soybean oil was administered orally with glass beads, and the number of residual beads in the stomach was counted 1h later. Both CRF and soybean oil inhibited gastric emptying dose-dependently. Ramosetron and itopride, a gastro-prokinetic agent, significantly reduced both CRF- and soybean oil-induced delays in gastric emptying, while an anti-diarrheal agent and spasmolytics aggravated them. Pretreatment with p-chlorophenylalanine for 2days to reduced the synthesis of endogenous 5-...Continue Reading

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Citations

Jan 26, 2013·Journal of Neurogastroenterology and Motility·Yoo Mi ParkHyojin Park
May 15, 2013·Journal of Neurogastroenterology and Motility·Tae Hee Lee
May 15, 2013·Journal of Neurogastroenterology and Motility·Yoo Mi Park, Hyojin Park
Oct 11, 2017·Journal of Neurogastroenterology and Motility·Takahisa YamasakiHiroto Miwa
May 9, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Maya MuramatsuHiroshi Hara
Feb 8, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Hiroshi YamawakiKatsuhiko Iwakiri
Apr 7, 2018·Canadian Journal of Gastroenterology & Hepatology·Yang YeCun-Zhi Liu
Sep 18, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Grant GreavesJonathan P Little

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