Inhibitory effect of some oxygenated stigmastane-type sterols on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice

Biological & Pharmaceutical Bulletin
Y KimuraT Tamura

Abstract

The oxygenated stigmastane-type sterols stigmastane-3 beta, 6 alpha-diol, stigmastane-3 beta, 6 beta-diol, 7 alpha-hydroxysitosterol and its diacetyl derivative, 7 beta-hydroxysitosterol and its diacetyl derivative, 7-oxositosterol, 4 beta-hydroxysitosterol, and stigmast-4-ene-3 beta, 6 beta-diol were evaluated with respect to their anti-inflammatory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. All of the sterols, with the exception of 7 alpha-hydroxysitosterol and its diacetyl derivative, were found to possess marked inhibitory activity. The 50% inhibitory dose of these compounds for TPA-inflammation (1 microgram) was 0.5--1.0 mg/ear.

Citations

Jun 28, 2011·Chemistry and Physics of Lipids·Guadalupe García-Llatas, María Teresa Rodríguez-Estrada
Sep 28, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A Otaegui-ArrazolaI Astiasarán
Nov 21, 2007·Progress in Lipid Research·Egbert HovenkampElke A Trautwein
Jan 28, 2015·Progress in Lipid Research·Tim VanmierloJerome J A Hendriks
Feb 5, 2014·Biochemical and Biophysical Research Communications·Yvonne O'CallaghanNora M O'Brien
Aug 10, 2011·Journal of Food Science·Xia LiXin-Hua Guo
May 15, 2001·Phytotherapy Research : PTR·A L ValverdeR M Kuster
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