Inhibitory effect of Streblus asper leaf-extract on adhesion of Candida albicans to denture acrylic

Journal of Ethnopharmacology
S TaweechaisupapongS Wongkham

Abstract

This in vitro study aimed at determining the effects of various sublethal concentrations of Streblus asper leaf ethanolic extract (SAE) on adherence of Candida albicans to acrylic surface. A colorimetric tetrazolium assay using (2,3)-bis (2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino)-carbonyl]-2H-tetrazolium hydroxide was used to make the quantitative determination. The SAE at a concentration equivalent to nystatin (6.24microg/ml) pinpointed the minimal exposure time of SAE in suppressing candidal adhesion to acrylic. Adhesion of Candida albicans to acrylic was determined after exposure to SAE for 1, 15, 30, 60, 120 and 180min. The minimum concentration of SAE that significantly reduced adherence (P<0.05) after a 4-h exposure was 31.25mg/ml. In addition, a significant reduction (P<0.01) of candidal adhesion to acrylic occurred after a 1min exposure to 62.5mg/ml of SAE. Pre-treatment of yeast with 62.5mg/ml of SAE for 1h before adhesion assay significant reduced the adherence as 20.54% compared to the untreated control, whereas the same treatment with acrylic strips did not show any effect. These findings indicate that exposure of Candida albicans to sublethal concentrations of SAE results in a reduction in the ability of th...Continue Reading

References

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Mar 18, 2000·Journal of Ethnopharmacology·S TaweechaisupapongS Chaiyarak
Mar 27, 2001·Phytotherapy Research : PTR·S WongkhamT Techanitiswad

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Citations

Mar 26, 2015·Journal of Enzyme Inhibition and Medicinal Chemistry·Pedro Henrique de Azambuja CarvalhoRafael Guerra Lund
Feb 26, 2008·Magnetic Resonance in Chemistry : MRC·Jun LiYong-Cheng Lin
Feb 20, 2020·Indian Journal of Clinical Biochemistry : IJCB·Md Shahed-Al-MahmudMd Rashidur Rahman

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