Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro

Urology
Raffaele CapassoAngelo A Izzo

Abstract

To evaluate the effect of St. John's wort (SJW), an effective and safe herbal antidepressant, on rat bladder contractility. Recent data have suggested a strong association between depression and urinary incontinence. Strips were cut from the bladder body and placed in organ baths containing Krebs solution. Contractions were induced by electrical field stimulation (EFS) and, in some experiments, by exogenous alpha,beta (alpha,beta)-methylene adenosine triphosphate. St. John's wort was significantly more active in inhibiting the EFS-induced contractions than the alpha,beta-methylene adenosine triphosphate-induced contractions, suggesting both a presynaptic site of action and a direct inhibition of bladder smooth muscle. The inhibitory effect of SJW on EFS-induced contractions was unaffected by methysergide, haloperidol, phentolamine plus propranolol (antagonists that block the action of the neurotransmitters 5-hydroxytriptamine, dopamine, and noradrenaline on their own receptors), the L-type calcium channel antagonist verapamil, capsazepine (which blocks the vanilloid receptor), or cannabinoid CB1 receptor antagonist SR141716A. However, the opioid receptor antagonist naloxone significantly reduced the inhibitory effect of SJW on ...Continue Reading

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Citations

Aug 2, 2013·International Journal of Impotence Research·C V OztekinM Cetinkaya
Aug 10, 2007·Journal of Natural Products·Peter L KatavicThomas E Prisinzano
Jan 4, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Raffaele CapassoAngelo A Izzo
Jan 3, 2007·Journal of the American Geriatrics Society·John A Taylor, George A Kuchel
Jul 5, 2013·Phytotherapy Research : PTR·Barbara RomanoFrancesca Borrelli
Nov 14, 2012·The Journal of Pharmacy and Pharmacology·Aurora ValeriFederica Pessina
Dec 15, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Charu SharmaShreesh Ojha
Jul 25, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·V SchulerU von Mandach
Dec 12, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Cornelia BetschartVerena Geissbühler
May 26, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Eveline Dischkaln StolzStela M K Rates

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