Inhibitory effect of the antimicrobial peptide BLP-7 against Propionibacterium acnes and its anti-inflammatory effect on acne vulgaris

Toxicon : Official Journal of the International Society on Toxinology
Yun WuGuangxian Zhang

Abstract

Propionibacterium acnes (P. acnes) is a Gram-positive commensal bacterium, which is involved in the pathogenesis and inflammation of acne vulgaris. An antimicrobial peptide named bombinin-like peptide 7 (BLP-7), which was determined from Bombina orientalis, has been shown to possess certain antibacterial activity. This study was carried out with synthesized BLP-7 on the basis of the antimicrobial and anti-inflammatory activities against P. acnes in vitro and in vivo. The minimal inhibitory concentration (MIC) of BLP-7 against P. acnes is 5 μM. And BLP-7 exhibits strong resistance to heat, pH and salt concentration, but no significant cytotoxicity to normal human epidermal keratinocytes (NHEKs). Using the co-culture of P. acnes and NHEKs, this study demonstrated that BLP-7 significantly reduced the production of interleukin (IL)-8 and granulocyte-macrophage colony stimulating factor (GM-CSF), as well as the expression of these two pro-inflammatory cytokines at the transcriptional level. In a separate study, using the rat ear edema model, BLP-7 significantly suppressed P. acnes-induced skin inflammation, reducing the ear thickness by 54.21% of the negative control group. These results suggest that due to its anti-P. acnes and ant...Continue Reading

References

Feb 20, 2003·Dermatology : International Journal for Clinical and Investigative Dermatology·A KoreckL Kemény
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philip T LiuRobert L Modlin
Oct 6, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·Jenny Kim
Apr 16, 2009·Biochimica Et Biophysica Acta·Maurizio SimmacoDonatella Barra
Jan 20, 2010·Clinics in Dermatology·Clio Dessinioti, Andreas D Katsambas
Jun 18, 2011·Trends in Biotechnology·Leonard T NguyenHans J Vogel
Feb 11, 2015·The Journal of Investigative Dermatology·Nathan W SchmidtGerard C L Wong
Nov 26, 2015·Nucleic Acids Research·Guangshun WangZhe Wang
Jan 1, 2015·Nature Reviews. Disease Primers·Sara Moradi TuchayiChristos C Zouboulis
Jul 15, 2016·Current Topics in Medicinal Chemistry·Katarzyna E Greber, Małgorzata Dawgul
Feb 22, 2017·Toxicon : Official Journal of the International Society on Toxinology·Manyi YangMaojun Zhou
Apr 4, 2017·Expert Opinion on Biological Therapy·Josep M SierraMiguel Viñas
Dec 6, 2017·Orthopaedics & Traumatology, Surgery & Research : OTSR·P Boisrenoult
Feb 8, 2018·The Journal of Investigative Dermatology·Eun-Jeong ChoiEun-Gyung Cho
Aug 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lu-Te ChuangPo-Jung Tsai
Aug 31, 2018·Journal of Oral and Maxillofacial Pathology : JOMFP·Shiva GuptaSameer Saxena
Oct 16, 2018·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Anna Herman, Andrzej P Herman
Jan 13, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natalja WeberUte Wölfle
Mar 25, 2019·Protein Expression and Purification·De-Mei MengZhen-Chuan Fan
Apr 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dasom CheonYangmee Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.