PMID: 16614480Apr 15, 2006Paper

Inhibitory effect of the coffee diterpene kahweol on carrageenan-induced inflammation in rats

BioFactors
Ji Young KimHye Gwang Jeong

Abstract

Previous studies reported that kahweol, a coffee-specific diterpene, inhibits cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression in cultured lipopolysaccharide-activated macrophages. The aim of this study was to confirm the anti-inflammatory effects of kahweol by examining its effect on the inflammatory response induced by carrageenan in a rat using an acute air pouch inflammation model. Kahweol significantly reduced the levels of the inflammatory process markers in the air pouch, such as the volume of exudates, the amount of protein and the number of leukocytes and neutrophils. The levels of nitrite, TNF-alpha and prostaglandin E2 (PGE2) were also markedly lower in the air pouch of the kahweol-treated animals than in the controls. Immunoblot analysis showed that kahweol reduced the COX-2 and iNOS expression level in the exudate cells. The histological examination showed that there was a lower inflammatory response in the pouch tissues from the kahweol-treated animals. In addition, kahweol significantly reduced the paw edema induced by carrageenan and also markedly reduced the level of PGE2 production in the inflamed paw. These results suggest that kahweol has significant anti-inflammatory effects in...Continue Reading

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Citations

Feb 16, 2012·Clinical and Experimental Pharmacology & Physiology·Luciana S GuzzoIgor Dg Duarte
Jun 26, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kyung Jin LeeHye Gwang Jeong
Mar 30, 2016·Phytotherapy Research : PTR·Md Torequl IslamAna Amélia de Carvalho Melo-Cavalcante
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Feb 7, 2018·International Journal of Food Sciences and Nutrition·Yi Zhang, Dian-Zhong Zhang
May 30, 2019·International Journal of Environmental Research and Public Health·Chin Yi ChanNorazlina Mohamed
Sep 5, 2019·International Journal of Molecular Sciences·Yaqi RenShuaiyu Wang
Dec 7, 2018·Natural Product Research·Simona PergolizziEugenia Rita Lauriano
Jul 8, 2017·International Journal of Environmental Research and Public Health·Kok-Yong ChinSoelaiman Ima-Nirwanaa
Dec 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nuntouchaporn HutachokSomdet Srichairatanakool
Aug 31, 2021·Critical Reviews in Food Science and Nutrition·Luigi BarreaGiovanna Muscogiuri

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