Inhibitory effect of the intravenous anesthetic, ketamine, on rat mesangial cell proliferation

Anesthesia and Analgesia
N JimiA Shigematsu

Abstract

We studied the effects of ketamine and propofol on rat cultured mesangial cell (MC) proliferation. The 72-h exposure to ketamine (1-100 microM) inhibited [3H]thymidine incorporation into the MC in a concentration-dependent manner. Propofol, however, was not effective at inhibition of MC proliferation at doses from 1 to 100 microM. Ketamine also decreased the cell number at clinically relevant concentrations and increased adenosine 3',5'-cyclic monophosphate (cAMP) levels in MC. We also studied the effects of ketamine on cytokine-induced [3H]thymidine incorporation into the cells. Ketamine decreased the tumor necrosis factor-alpha (TNF-alpha)-, interleukin 1 (IL-1)-, and interleukin 6 (IL-6)-induced [3H]thymidine incorporation into the cells. It also decreased angiotensin II (Ag II)-induced [3H]thymidine incorporation. These results suggest that ketamine has inhibitory effects on MC proliferation, but that propofol does not. Because ketamine inhibits TNF-alpha-, IL-1-, and IL-6-induced MC proliferation, it may be useful in suppressing the cell growth clinically.

References

Dec 1, 1979·British Journal of Anaesthesia·J IdvallP Stenberg
Dec 1, 1992·Journal of the American Society of Nephrology : JASN·G WolfR A Stahl
Mar 1, 1992·Kidney International·L BaudA Amrani
Jan 1, 1991·Nephron·E N Wardle
Dec 1, 1990·Immunology Today·T HiranoT Kishimoto
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J F Bazan
Aug 1, 1990·Kidney International·C RuefD L Coleman
Feb 1, 1982·Anesthesiology·P F WhiteA J Trevor
Jan 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·N P MallickN Selwood
Aug 15, 1994·Annals of the New York Academy of Sciences·B Beutler, C Van Huffel
Jul 1, 1993·Nature·S J SlaterC D Stubbs
Jul 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·T KieferU Kuhlmann

❮ Previous
Next ❯

Citations

Dec 23, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·G E HillC W Whitten
Oct 14, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T SakaiJ M Lipton
Oct 12, 1999·Journal of Pain and Symptom Management·M StotzH Gerber
Feb 20, 2009·Biopharmaceutics & Drug Disposition·Ju-Hee OhYoung-Joo Lee
Apr 10, 2010·Journal of Pharmacological Sciences·Kouichiro MinamiYasuhito Uezono
Oct 27, 2004·Anesthesia and Analgesia·Yousuke ShigaKim Sung-Teh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.