Inhibitory effect of the mi transcription factor encoded by the mutant mi allele on GA binding protein-mediated transcript expression in mouse mast cells.

Blood
Eiichi MoriiY Kitamura

Abstract

The mi transcription factor (MITF) is a basic-helix-loop-helix leucine zipper (bHLH-Zip) transcription factor that is important for the development of mast cells. Mast cells of mi/mi genotype express normal amounts of abnormal MITF (mi-MITF), whereas mast cells of tg/tg genotype do not express any MITFs. The synthesis of heparin is abnormal in the skin mast cells of mi/mi mice. Because N-deacetylase/N-sulfotransferase 2 (NDST-2) is essential for the synthesis of heparin, the amount of NDST-2 messenger RNA (mRNA) was compared among cultured mast cells (CMCs) of +/+, mi/mi, and tg/tg genotypes. The NDST-2 mRNA was detected by in situ hybridization in the skin mast cells of +/+ and tg/tg mice, but not in the skin mast cells of mi/mi mice. The amount of NDST-2 mRNA decreased significantly in CMCs derived from mi/mi mice when compared to the values of +/+ and tg/tg mice, suggesting that the defective form of MITF inhibited the expression of the NDST-2 transcript. The expression of NDST-2 transcript was mediated by the GGAA motif located in the 5'-untranslated region. GA binding protein (GABP) bound the GGAA motif and increased the amount of NDST-2 transcript. The mi-MITF appeared to inhibit the ability of GABP to express NDST-2 tran...Continue Reading

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Citations

Mar 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jenny PrestoLena Kjellén
Dec 11, 2008·Pigment Cell & Melanoma Research·Keith S HoekEirikur Steingrimsson
Oct 9, 2012·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Johan Kreuger, Lena Kjellén
Aug 7, 2007·International Journal of Hematology·Eiichi Morii
Aug 26, 2006·Immunology and Allergy Clinics of North America·Yukihiko KitamuraAkihiko Ito
May 15, 2007·Immunological Reviews·Irit Carmi, Ehud Razin
Feb 26, 2013·Journal of Internal Medicine·U Lindahl, L Kjellén
Oct 31, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M J Joliat, L D Shultz
Dec 1, 2004·Annual Review of Genetics·Eiríkur SteingrímssonNancy A Jenkins
May 10, 2012·PLoS Genetics·Juying LiDavid E Fisher
Oct 20, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Tatsuki R KataokaToru Nakano
Dec 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amir H ShahlaeeClifford M Takemoto
Oct 26, 2018·Emerging Topics in Life Sciences·Bryan E Thacker, Susan T Sharfstein

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