Inhibitory effect of three C-glycosylflavonoids from Cymbopogon citratus (Lemongrass) on human low density lipoprotein oxidation.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Roxana OrregoJosé Cheel

Abstract

This study assessed the inhibitory effect of three C-glycosylflavonoids from Cymbopogon citratus leaves--isoorientin (1), swertiajaponin (2) and isoorientin 2"-Orhamnoside (3)--on human LDL oxidation. Isolated LDL was incubated with compounds 1-3 and the kinetics of lipid peroxidation were assessed by conjugated diene and malondialdehyde-thiobarbituric acid reactive substances (MDA-TBARS) formation after addition of copper ions. Significant differences (p < 0.05) between the lag time phase of the control and the lag time phase in the presence of the compounds 1 (0.25 microM) and 2 (0.50 microM) were observed. After five hours of incubation all three compounds showed a significant inhibitory effect on MDA-TBARS formation with respect to the control. After six hours of incubation only compound 1 kept a remarkable antioxidant effect. This study demonstrates that isoorientin (1) is an effective inhibitor of in vitro LDL oxidation. As oxidative damage to LDL is a key event in the formation of atherosclerotic lesions, the use of this natural antioxidant may be beneficial to prevent or attenuate atherosclerosis.

Citations

Jul 28, 2012·Journal of Advanced Pharmaceutical Technology & Research·K M Sakthivel, C Guruvayoorappan
Dec 26, 2015·Journal of Ethnopharmacology·Gustavo CostaMaria Teresa Batista
Nov 13, 2014·Journal of the Science of Food and Agriculture·Filipa TavaresMaria Teresa Batista
Jul 14, 2016·Journal of Food Science and Technology·Sinjitha S NambiarK A Anu Appaiah
Mar 31, 2017·Current Pharmaceutical Design·Ryszard Amarowicz, Ronald B Pegg
May 31, 2019·International Journal of Molecular Sciences·Adriano Costa de CamargoAndrés R Schwember
Aug 26, 2020·Anatomy & Cell Biology·Gbadamosi Ismail TemitayoOlajide Olayemi Joseph
Oct 20, 2020·Frontiers in Pharmacology·Dâmaris SilveiraMichael Heinrich
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Raquel SousaMaria Eugénia Pina

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