Inhibitory effect of trichodermanone C, a sorbicillinoid produced by Trichoderma citrinoviride associated to the green alga Cladophora sp., on nitrite production in LPS-stimulated macrophages

Natural Product Research
Roberta MarraAnna Andolfi

Abstract

From the green alga Cladophora sp. collected in Italy, the marine fungal strain A12 of Trichoderma citrinoviride was isolated, identified and characterized. LC-MS qTOF analysis was applied to perform a metabolic profile of the fungal culture. Chromatographic techniques and spectroscopic methods were used to isolate and characterize the major secondary metabolites produced by this strain in liquid culture. In particular, four known sorbicillinoids (trichodermanone C, spirosorbicillinol A, vertinolide and sorbicillin) were purified and identified, together with 2-phenylethanol and tyrosol. Moreover, metabolomic analysis allowed to detect small amounts of trichodimerol, rezishanone A, 2',3'-dihydrosorbicillin and bisvertinol. For the first time a significant inhibitory effect on nitrite levels has been shown for trichodermanone C in lipopolysaccharide-stimulated J774A.1 macrophages.

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Citations

May 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marina DellaGrecaAnna Andolfi
Nov 14, 2019·Marine Drugs·Jianzhou XuShan He
May 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gaetano De TommasoAnna Andolfi
Jun 24, 2020·Plants·Monika SoodAnket Sharma
May 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Seyed Mostafa GoldansazMaria Valeria D'Auria
Feb 12, 2021·Natural Product Reports·Anthony R CarrollMichèle R Prinsep
Sep 23, 2021·Natural Product Research·Xin-Yue MaNai-Yun Ji

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Datasets Mentioned

BETA
EGE-K-130

Methods Mentioned

BETA
nuclear magnetic resonance
NMR

Software Mentioned

BLASTn
MassHunter

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