Inhibitory effect of tyrphostin on the replication of herpes simplex virus type 1

Archives of Virology
Y YuraM Sato

Abstract

Tyrphostins 9 and 47, inhibitors of protein-tyrosine kinase, inhibited the replication of herpes simplex virus type 1 (HSV-1), whereas tyrophostin 1, which does not inhibit protein-tyrosine kinase, did not affect the replication of HSV-1. The inhibitory effect of tyrphostin 9 was more potent than that of tyrphostin 47, and the IC50 of tyrphostin 9 was 40 nM. Sodium orthovanadate, an inhibitor of protein phosphotyrosine phosphatase, increased HSV-1 plaque formation and its effect was partly reversed by tyrphostin 9. The phosphorylation of viral phosphoproteins was decreased by tyrphostin 9 in a dose-dependent manner, but the tyrphostin 9-induced reduction of protein synthesis was not dose-dependent. At the late stage of infection, tyrosine phosphorylation was demonstrated in HSV-1 phosphoproteins. These results indicate that protein-tyrosine kinase is involved in the replication of HSV-1 and that tyrphostin can inhibit the synthesis and post-translational phosphorylation of the viral proteins.

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Citations

Jan 5, 2005·Biochemical and Biophysical Research Communications·Shue-Ling RaungChun-Jung Chen
Apr 30, 2003·Journal of Virology·J B JohnstonGrant McFadden
May 10, 2019·Antiviral Research·Zoé LamaCécile Lagaudrière-Gesbert

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