PMID: 7536335Dec 15, 1994Paper

Inhibitory effect of vasoactive intestinal peptide (VIP) on phagocytosis in mouse peritoneal macrophages

Regulatory Peptides
M IchinoseT Maeno

Abstract

The effect of VIP on phagocytosis in peritoneal macrophages was examined by means of flow cytometry (FCM). This assay revealed that VIP suppressed phagocytosis in a dose-dependent manner. VIP(1-12) did not suppress phagocytosis. VIP(10-28) was more suppressive than VIP(1-28). A known VIP-antagonist (N-Ac-Tyr1,D-Phe2)-growth hormone-releasing factor (GRF) (1-29)-NH2 suppressed phagocytosis less than VIP. Control phagocytosis was partially suppressed in Ca(2+)-free solution. Phagocytosis was suppressed by VIP further in Ca(2+)-free solution than in the normal solution. Phagocytosis was suppressed in a known phosphodiesterase inhibitor IBMX-containing solution. The degree of suppression by VIP was the same in the presence or the absence of IBMX. These results suggest that VIP suppresses extracellular Ca(2+)-dependent and -independent phagocytosis, that the C-terminal fragment of VIP is essential for VIP action, that the suppression is mediated by cAMP and that the inhibition of macrophage phagocytosis by VIP is one of the mechanisms which modulates immune responses by the nervous system.

References

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Citations

Aug 1, 1996·Journal of Neuroimmunology·M C JohnsonD Ganea
Jan 1, 1996·Advances in Neuroimmunology·M De la FuenteR P Gomariz
Jun 1, 2004·Pharmacological Reviews·Mario DelgadoDoina Ganea
Dec 26, 1996·Annals of the New York Academy of Sciences·H TangD Ganea
May 29, 2004·Protein Engineering, Design & Selection : PEDS·Takeshi TennoHidekazu Hiroaki
Mar 17, 2020·Cellular and Molecular Life Sciences : CMLS·Indiwari GopallawaRobert J Lee

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