Inhibitory effect of zinc oxide on contact allergy due to colophony

Contact Dermatitis
T A SöderbergG Hallmans

Abstract

Contact allergy to a wound dressing with an adhesive mass consisting of colophony, zinc oxide and rubber (Mezinc) was studied in 179 patients with a history of eczema. 12 patients were found to be allergic to colophony, whereas only 4 of these patients also showed a positive patch test reaction to the wound dressing. 14 patients with verified moderate contact allergy to colophony were patch tested with adhesive mass (10%), Portuguese colophony (10%), zinc oxide (10%), purified resin acids (10%), and Portuguese colophony (10%), in combination with zinc oxide. Only 3 patients reacted to the adhesive mass, whereas all patients showed a positive patch test reaction to Portuguese colophony. A combination of zinc oxide (10%) with Portuguese colophony (10%) provoked a positive patch test reaction in only 5 of these 14 patients. An allergic reaction to abietic acid (90-95% purity) was found in 7 patients and to neoabietic acid (99 + %) in 3 patients, whereas no reactions to dehydroabietic (99 + %), isopimaric (99 + %) or levopimaric acids (98 + %) were found.

References

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Citations

Jun 1, 1995·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A JohanssonR Gref
Sep 1, 1995·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·B SunzelL Hänström
Jan 5, 2000·Contact Dermatitis·A M Downs, J E Sansom
Jun 1, 1994·Acta Odontologica Scandinavica·A Hensten-Pettersen, N Jacobsen
Jan 25, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Alan B G LansdownMagnus S Agren
Nov 3, 2004·Journal of Wound Care·M S Agren, U Mirastschijski

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