PMID: 38633Jan 1, 1978

Inhibitory effect on gastric motility of chloroquine and mepacrine

Acta physiologica Academiae Scientiarum Hungaricae
E MinkerT Kákár

Abstract

Measured on isolated rat-stomach fundus strips, the isolated cervical sympathetic trunk, and on the superior cervical ganglion, chloroquine and mepacrine have parasympatholytic, spasmolytic, ganglionic blocking and local anaesthetic effects. On rising the doses these manifest themselves in a given sequence. On the basis of this fact it is concluded that the inhibition of gastric motility by chloroquine and mepacrine in the rat, is based on the parasympatholytic property of the drugs in question.

Related Concepts

Depression, Chemical
Sympathetic Nervous System
Chloroquine
Parasympatholytics
Entire Superior Cervical Ganglion
Quinacrine
Antispasmodics
Ganglia
Intestinal Motility
Antispasmodic Effect

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