Inhibitory effects against α-glucosidase and α-amylase of the flavonoids-rich extract from Scutellaria baicalensis shoots and interpretation of structure-activity relationship of its eight flavonoids by a refined assign-score method

Chemistry Central Journal
Ke LiYujun Liu

Abstract

A flavonoids-rich extract of Scutellaria baicalensis shoots and its eight high content flavonoids were investigated for their inhibitory effects against α-glucosidase and α-amylase. Results show that abilities of the extract in inhibiting the two enzymes were obviously higher than those of acarbose. Moreover, inhibitory abilities of all the eight individual flavonoids against the two enzymes show exactly a same order (i.e., apigenin > baicalein > scutellarin > chrysin > apigenin-7-O-glucuronide > baicalin > chrysin-7-O-glucuronide > isocarthamidin-7-O-glucuronide), and their structure-activity relationship could be well-interpretated by the refined assign-score method. Furthermore, based on the inhibitory abilities and their contents in the extract, it was found that the eight flavonoids made predominant contributions, among which baicalein and scutellarin played roles as preliminary contributors, to overall inhibitory effects of the extract against the two enzymes. Beyond these, contributions of the eight flavonoids to the overall enzyme inhibitory activity were compared with those to the overall antioxidant activity characterized in our recent study, and it could be inferred that within the basic flavonoid structure the hydro...Continue Reading

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Citations

Mar 27, 2020·International Journal of Molecular Sciences·Saikat DewanjeeVincenzo De Feo
Oct 28, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Elida Paula Dini de FrancoPatrícia de Oliveira Carvalho
Aug 19, 2020·Annual Review of Entomology·May R Berenbaum, Bernarda Calla
Aug 27, 2019·European Journal of Pharmacology·Rubiya KhursheedKamal Dua
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jesus Ivan Solares-PascasioClaudia Velazquez
Apr 4, 2021·Pharmaceuticals·Christina Vijayaraghavan SathynathanMary Elizabeth Gnanambal Krishnan
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Patchima SithisarnPongtip Sithisarn

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