Inhibitory effects of a new antiallergic agent, azelastine, on passive cutaneous anaphylaxis and expulsion of Nippostrongylus brasiliensis

Immunopharmacology
R KajiS Kojima

Abstract

A new antiallergic agent, 4-(p-chlorobenzyl)-2-[N-methyl-perhydroazepinyl-(4)]-1-(2H)-phthalazinone hydrochloride (azelastine), was found to exert inhibitory effects on passive cutaneous anaphylaxis in the rat and on expulsion of Nippostrongylus brasiliensis from the rat intestine when this agent was administered intravenously at appropriate doses.

Citations

Nov 19, 1991·European Journal of Pharmacology·N SennR Garay

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.