Inhibitory effects of Actinidia polygama extract and cyclosporine A on OVA-induced eosinophilia and bronchial hyperresponsiveness in a murine model of asthma

International Immunopharmacology
Young-Cheol LeeJang-Cheon Lee

Abstract

Actinidia polygama is one of the well known herb used in oriental medicine for treatment of anti-inflammatory and many allergic diseases. Anti-asthmatic effects of A. polygama in the development of OVA-induced eosinophilia and hyperresponsiveness in murine model of asthma have not been fully investigated in vivo. Cyclosporine A (CsA) has been shown to inhibit single allergen-induced allergic inflammation such as eosinophilic and lymphocytic infiltration and mRNA expression for interleukin (IL)-4 and IL-5. Asthma is a chronic inflammatory disease of the mucosa and is associated with excess production of Th2 cytokines and eosinophil influx in lung. To clarify the anti-inflammatory and anti-asthmatic effects of A. polygama and CsA, we examined the influence of A. polygama fructus extract (APF) and CsA on the development of pulmonary eosinophilic inflammation in murine model of asthma. Our results have shown that APF and CsA have profound inhibitory effects on the accumulation of eosinophills into airways, with the reduction of eosinophil and total lung leukocyte number by reducing IL-4, IL-5, IL-13 and IgE levels in the BALF. Moreover, APF decreased eosinophil CCR3 expression and CD11b expression in lung cells. These results indic...Continue Reading

References

May 1, 1991·The Journal of Allergy and Clinical Immunology·A B Kay
Aug 1, 1990·The American Review of Respiratory Disease·R DjukanovićS T Holgate
Oct 11, 1990·The New England Journal of Medicine·J BousquetP Godard
Feb 1, 1990·The Journal of Allergy and Clinical Immunology·G J Gleich
Mar 1, 1989·The American Review of Respiratory Disease·R BeasleyS T Holgate
Dec 1, 1994·The Journal of Allergy and Clinical Immunology·T T KungR W Chapman
Sep 1, 1994·The Journal of Allergy and Clinical Immunology·B S Bochner, R P Schleimer
May 29, 1998·The New England Journal of Medicine·M E Rothenberg
Aug 26, 1998·Thorax·J LötvallP O'Byrne
Aug 3, 1999·The Journal of Clinical Investigation·G CieslewiczE W Gelfand
Nov 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C BerendsH F Kauffman
Feb 2, 2002·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·H TanakaH Nagai
Apr 20, 2002·Current Opinion in Allergy and Clinical Immunology·S Romagnani
Feb 25, 2003·Molecular Therapy : the Journal of the American Society of Gene Therapy·Phillip Factor
Nov 12, 2003·The Journal of Allergy and Clinical Immunology·Minqi HaoAndre Nel

❮ Previous
Next ❯

Citations

Jul 31, 2008·American Journal of Respiratory Cell and Molecular Biology·Bruna P F FonsecaJoão P B Viola
Dec 19, 2008·Disease Models & Mechanisms·Anthony T Nials, Sorif Uddin
Jul 6, 2010·Cellular and Molecular Life Sciences : CMLS·Andrzej Galat, Jacqueline Bua
Aug 31, 2012·Phytotherapy Research : PTR·Giciane C VieiraMarcia R Piuvezam
Feb 1, 2007·The American Journal of Chinese Medicine·Jung-Chun LiaoWen-Huang Peng
Dec 21, 2012·Molecular Medicine Reports·Yoon-Young SungHo Kyoung Kim
Jan 29, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Lin Ho WongPang Ong Wong
Apr 25, 2020·Journal of Ethnopharmacology·Zhejie ChenYitao Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.