PMID: 9159651Feb 1, 1997Paper

Inhibitory effects of acupuncture manipulation and focal electrical stimulation of the nucleus submedius on a viscerosomatic reflex in anesthetized rats

The Japanese Journal of Physiology
E Sumiya, K Kawakita

Abstract

To examine the participation of nucleus submedius (Sm) in the medial thalamus of pain inhibitory systems, we investigated the effects of acupuncture and focal electrical stimulation of the Sm and adjacent brain sites (0.3 ms, 50 Hz, 50-100 microA, 10 s) on the EMG activity of the external oblique muscle evoked by colorectal distension in urethane-anesthetized Wistar rats. The viscerosomatic reflex (VSR) activity was suppressed after the administration of morphine (1.0 mg/kg, i.v.) and the effect was reversed by naloxone (0.5 mg/kg, i.v.). Transection of the spinal cord at the Th2 level also eliminated the VSR. Acupuncture manipulation applied to the cheek (manual rotation at 1 Hz) suppressed the VSR, and this inhibition was eliminated by microinjections of lidocaine into the bilateral Sm nuclei (0.5 microliter of 1.0% solution). Electrical stimulation in the ventral part but not the dorsal part of the Sm suppressed the VSR. The inhibition of the VSR induced by electrical stimulation of the Sm was not reversed by the administration of naloxone (1.0 mg/kg, i.v.). Electrical stimulation of the adjacent medial thalamic nuclei (mediodorsal nucleus (MD) or centromedial nucleus (CM)) and ventrobasal complex (VB) of the thalamus had ve...Continue Reading

Citations

May 24, 2005·Neuroscience Letters·Eva BarkovaJohn W Downie
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Kaoru Okada, Kenji Kawakita
Jun 27, 2006·Journal of Pharmacological Sciences·Kenji KawakitaKinya Kuriyama
Jul 15, 2006·The Journal of Physiological Sciences : JPS·Sun Kwang KimByung-Il Min
Oct 7, 2000·The Journal of the Association of Nurses in AIDS Care : JANAC·B SwansonD Cronin-Stubbs

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